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Genetic regulation of OAS1 nonsense-mediated decay underlies association with COVID-19 hospitalization in patients of European and African ancestries
DC Field | Value | Language |
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dc.contributor.author | Banday, A. Rouf | - |
dc.contributor.author | Stanifer, Megan L. | - |
dc.contributor.author | Florez-Vargas, Oscar | - |
dc.contributor.author | Onabajo, Olusegun O. | - |
dc.contributor.author | Papenberg, Brenen W. | - |
dc.contributor.author | Zahoor, Muhammad A. | - |
dc.contributor.author | Mirabello, Lisa | - |
dc.contributor.author | Ring, Timothy J. | - |
dc.contributor.author | Lee, Chia-Han | - |
dc.contributor.author | Albert, Paul S. | - |
dc.contributor.author | Andreakos, Evangelos | - |
dc.contributor.author | Arons, Evgeny | - |
dc.contributor.author | Barsh, Greg | - |
dc.contributor.author | Biesecker, Leslie G. | - |
dc.contributor.author | Boyle, David L. | - |
dc.contributor.author | Brahier, Mark S. | - |
dc.contributor.author | Burnett-Hartman, Andrea | - |
dc.contributor.author | Carrington, Mary | - |
dc.contributor.author | Chang, Euijin | - |
dc.contributor.author | Choe, Pyoeng Gyun | - |
dc.contributor.author | Chisholm, Rex L. | - |
dc.contributor.author | Colli, Leandro M. | - |
dc.contributor.author | Dalgard, Clifton L. | - |
dc.contributor.author | Dude, Carolynn M. | - |
dc.contributor.author | Edberg, Jeff | - |
dc.contributor.author | Erdmann, Nathan | - |
dc.contributor.author | Feigelson, Heather S. | - |
dc.contributor.author | Fonseca, Benedito A. | - |
dc.contributor.author | Firestein, Gary S. | - |
dc.contributor.author | Gehring, Adam J. | - |
dc.contributor.author | Guo, Cuncai | - |
dc.contributor.author | Ho, Michelle | - |
dc.contributor.author | Holland, Steven | - |
dc.contributor.author | Hutchinson, Amy A. | - |
dc.contributor.author | Im, Hogune | - |
dc.contributor.author | Irby, Les'Shon | - |
dc.contributor.author | Ison, Michael G. | - |
dc.contributor.author | Joseph, Naima T. | - |
dc.contributor.author | Kim, Hong Bin | - |
dc.contributor.author | Kreitman, Robert J. | - |
dc.contributor.author | Korf, Bruce R. | - |
dc.contributor.author | Lipkin, Steven M. | - |
dc.contributor.author | Mahgoub, Siham M. | - |
dc.contributor.author | Mohammed, Iman | - |
dc.contributor.author | Paschoalini, Guilherme L. | - |
dc.contributor.author | Pacheco, Jennifer A. | - |
dc.contributor.author | Peluso, Michael J. | - |
dc.contributor.author | Rader, Daniel J. | - |
dc.contributor.author | Redden, David T. | - |
dc.contributor.author | Ritchie, Marylyn D. | - |
dc.contributor.author | Rosenblum, Brooke | - |
dc.contributor.author | Ross, M. Elizabeth | - |
dc.contributor.author | Anna, Hanaisa P. Sant | - |
dc.contributor.author | Savage, Sharon A. | - |
dc.contributor.author | Sharma, Sudha | - |
dc.contributor.author | Siouti, Eleni | - |
dc.contributor.author | Smith, Alicia K. | - |
dc.contributor.author | Triantafyllia, Vasiliki | - |
dc.contributor.author | Vargas, Joselin M. | - |
dc.contributor.author | Vargas, Jose D. | - |
dc.contributor.author | Verma, Anurag | - |
dc.contributor.author | Vij, Vibha | - |
dc.contributor.author | Wesemann, Duane R. | - |
dc.contributor.author | Yeager, Meredith | - |
dc.contributor.author | Yu, Xu | - |
dc.contributor.author | Zhang, Yu | - |
dc.contributor.author | Boulant, Steeve | - |
dc.contributor.author | Chanock, Stephen J. | - |
dc.contributor.author | Feld, Jordan J. | - |
dc.contributor.author | Prokunina-Olsson, Ludmila | - |
dc.date.accessioned | 2022-10-05T04:38:36Z | - |
dc.date.available | 2022-10-05T04:38:36Z | - |
dc.date.created | 2022-08-30 | - |
dc.date.issued | 2022-08 | - |
dc.identifier.citation | Nature Genetics, Vol.54 No.8, pp.1103-1116 | - |
dc.identifier.issn | 1061-4036 | - |
dc.identifier.uri | https://hdl.handle.net/10371/185473 | - |
dc.description.abstract | The chr12q24.13 locus encoding OAS1-OAS3 antiviral proteins has been associated with coronavirus disease 2019 (COVID-19) susceptibility. Here, we report genetic, functional and clinical insights into this locus in relation to COVID-19 severity. In our analysis of patients of European (n = 2,249) and African (n = 835) ancestries with hospitalized versus nonhospitalized COVID-19, the risk of hospitalized disease was associated with a common OAS1 haplotype, which was also associated with reduced severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) clearance in a clinical trial with pegIFN-lambda 1. Bioinformatic analyses and in vitro studies reveal the functional contribution of two associated OAS1 exonic variants comprising the risk haplotype. Derived human-specific alleles rs10774671-A and rs1131454-A decrease OAS1 protein abundance through allele-specific regulation of splicing and nonsense-mediated decay (NMD). We conclude that decreased OAS1 expression due to a common haplotype contributes to COVID-19 severity. Our results provide insight into molecular mechanisms through which early treatment with interferons could accelerate SARS-CoV-2 clearance and mitigate against severe COVID-19. | - |
dc.language | 영어 | - |
dc.publisher | Nature Publishing Group | - |
dc.title | Genetic regulation of OAS1 nonsense-mediated decay underlies association with COVID-19 hospitalization in patients of European and African ancestries | - |
dc.type | Article | - |
dc.identifier.doi | 10.1038/s41588-022-01113-z | - |
dc.citation.journaltitle | Nature Genetics | - |
dc.identifier.wosid | 000825196100001 | - |
dc.identifier.scopusid | 2-s2.0-85134324868 | - |
dc.citation.endpage | 1116 | - |
dc.citation.number | 8 | - |
dc.citation.startpage | 1103 | - |
dc.citation.volume | 54 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Kim, Hong Bin | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
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