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Dehydroglyasperin D Suppresses Melanin Synthesis through MITF Degradation in Melanocytes
DC Field | Value | Language |
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dc.contributor.author | Baek, Eun Ji | - |
dc.contributor.author | Ha, Yu-Bin | - |
dc.contributor.author | Kim, Ji Hye | - |
dc.contributor.author | Lee, Ki Won | - |
dc.contributor.author | Lim, Soon Sung | - |
dc.contributor.author | Kang, Nam Joo | - |
dc.date.accessioned | 2022-10-11T02:10:39Z | - |
dc.date.available | 2022-10-11T02:10:39Z | - |
dc.date.created | 2022-09-15 | - |
dc.date.issued | 2022-08 | - |
dc.identifier.citation | Journal of Microbiology and Biotechnology, Vol.32 No.8, pp.982-988 | - |
dc.identifier.issn | 1017-7825 | - |
dc.identifier.uri | https://hdl.handle.net/10371/185769 | - |
dc.description.abstract | Licorice (Glycyrrhiza) has been used as preventive and therapeutic material for hyperpigmentation disorders. Previously, we isolated noble compounds including dehydroglyasperin C (DGC), dehydroglyasperin D (DGD) and isoangustone A (IAA) from licorice hexane/ethanol extracts. However, their anti-melanogenic effects and underlying molecular mechanisms are unknown. The present study compared effects of DGC, DGD and IAA on pigmentation in melan-a melanocytes and human epidermal melanocytes (HEMn). DGD exerted the most excellent anti-melanogenic effect, followed by DGC and IAA at non-cytotoxic concentrations. In addition, DGD significantly inhibited tyrosinase activity in vitro cell-free system and cell system. Western blot result showed that DGD decreased expression of microphthalmia-associated transcription factor (MITF), tyrosinase and tyrosinase-related protein-1 (TRP-1) in melan-a cells and HEMn cells. DGD induced phosphorylation of MITF, ERK and Akt signal pathway promoting MITF degradation system. However, DGD did not influence p38 and cAMP-dependent protein kinase (PKA)/CREB signal pathway in melan-a cells. These result indicated that DGD inhibited melanogenesis not only direct regulation of tyrosinase but also modulating intracellular signaling related with MITF level. Collectively, these results suggested a protective role for DGD against melanogenesis. | - |
dc.language | 영어 | - |
dc.publisher | 한국미생물·생명공학회 | - |
dc.title | Dehydroglyasperin D Suppresses Melanin Synthesis through MITF Degradation in Melanocytes | - |
dc.type | Article | - |
dc.identifier.doi | 10.4014/jmb.2207.07043 | - |
dc.citation.journaltitle | Journal of Microbiology and Biotechnology | - |
dc.identifier.wosid | 000850082400005 | - |
dc.identifier.scopusid | 2-s2.0-85137126666 | - |
dc.citation.endpage | 988 | - |
dc.citation.number | 8 | - |
dc.citation.startpage | 982 | - |
dc.citation.volume | 32 | - |
dc.identifier.kciid | ART002867410 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Lee, Ki Won | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
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