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Supplementary role of left ventricular global longitudinal strain for predicting sudden cardiac death in hypertrophic cardiomyopathy
DC Field | Value | Language |
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dc.contributor.author | Lee, Hyun-Jung | - |
dc.contributor.author | Kim, Hyung-Kwan | - |
dc.contributor.author | Lee, Sang Chol | - |
dc.contributor.author | Kim, Jihoon | - |
dc.contributor.author | Park, Jun-Bean | - |
dc.contributor.author | Hwang, In-Chang | - |
dc.contributor.author | Choi, You-Jung | - |
dc.contributor.author | Lee, Seung-Pyo | - |
dc.contributor.author | Chang, Sung-A | - |
dc.contributor.author | Lee, Whal | - |
dc.contributor.author | Park, Eun-Ah | - |
dc.contributor.author | Cho, Goo-Yeong | - |
dc.contributor.author | Kim, Yong-Jin | - |
dc.date.accessioned | 2022-10-12T00:54:33Z | - |
dc.date.available | 2022-10-12T00:54:33Z | - |
dc.date.created | 2022-07-11 | - |
dc.date.created | 2022-07-11 | - |
dc.date.created | 2022-07-11 | - |
dc.date.created | 2022-07-11 | - |
dc.date.created | 2022-07-11 | - |
dc.date.created | 2022-07-11 | - |
dc.date.created | 2022-07-11 | - |
dc.date.created | 2022-07-11 | - |
dc.date.created | 2022-07-11 | - |
dc.date.created | 2022-07-11 | - |
dc.date.issued | 2022-07 | - |
dc.identifier.citation | European Heart Journal Cardiovascular Imaging, Vol.23 No.8, pp.jeab187-1116 | - |
dc.identifier.issn | 2047-2404 | - |
dc.identifier.uri | https://hdl.handle.net/10371/185912 | - |
dc.description.abstract | Aims We investigated the prognostic role of left ventricular global longitudinal strain (LV-GLS) and its incremental value to established risk models for predicting sudden cardiac death (SCD) in patients with hypertrophic cardiomyopathy (HCM). Methods and results LV-GLS was measured with vendor-independent software at a core laboratory in a cohort of 835 patients with HCM (aged 56.3 +/- 12.2 years) followed-up for a median of 6.4 years. The primary endpoint was SCD events, including appropriate defibrillator therapy, within 5 years after the initial evaluation. The secondary endpoint was a composite of SCD events, heart failure admission, heart transplantation, and all-cause mortality. Twenty (2.4%) and 85 (10.2%) patients experienced the primary and secondary endpoints, respectively. Lower absolute LV-GLS quartiles, especially those worse than the median (-15.0%), were associated with progressively higher SCD event rates (P = 0.004). LV-GLS was associated with an increased risk for the primary endpoint, independent of the LV ejection fraction, apical aneurysm, and 2014 European Society of Cardiology (ESC) risk score [adjusted hazard ratio (aHR) 1.14, 95% confidence interval (CI) 1.02-1.28] or 2011 American College of Cardiology/American Heart Association (ACC/AHA) risk factors (aHR 1.18, 95% CI 1.05-1.32). LV-GLS was also associated with a higher risk for the composite secondary endpoint (aHR 1.06, 95% CI 1.01-1.12). The addition of LV-GLS enhanced the performance of the ESC risk score (C-statistic 0.756 vs. 0.842, P = 0.007) and the 2011 ACC/AHA risk factor strategy (C-statistic 0.743 vs. 0.814, P = 0.007) for predicting SCD. Conclusion LV-GLS is an important prognosticator in patients with HCM and provides additional information to established risk stratification strategies for predicting SCD. | - |
dc.language | 영어 | - |
dc.publisher | Oxford University Press | - |
dc.title | Supplementary role of left ventricular global longitudinal strain for predicting sudden cardiac death in hypertrophic cardiomyopathy | - |
dc.type | Article | - |
dc.identifier.doi | 10.1093/ehjci/jeab187 | - |
dc.citation.journaltitle | European Heart Journal Cardiovascular Imaging | - |
dc.identifier.wosid | 000756565000001 | - |
dc.identifier.scopusid | 2-s2.0-85134855366 | - |
dc.citation.endpage | 1116 | - |
dc.citation.number | 8 | - |
dc.citation.startpage | jeab187 | - |
dc.citation.volume | 23 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Kim, Hyung-Kwan | - |
dc.contributor.affiliatedAuthor | Lee, Whal | - |
dc.contributor.affiliatedAuthor | Cho, Goo-Yeong | - |
dc.contributor.affiliatedAuthor | Kim, Yong-Jin | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | SPECKLE TRACKING ECHOCARDIOGRAPHY | - |
dc.subject.keywordPlus | CARDIOVERTER-DEFIBRILLATOR THERAPY | - |
dc.subject.keywordPlus | 2014 EUROPEAN-SOCIETY | - |
dc.subject.keywordPlus | MYOCARDIAL FIBROSIS | - |
dc.subject.keywordPlus | CARDIOLOGY GUIDELINES | - |
dc.subject.keywordPlus | 2-DIMENSIONAL STRAIN | - |
dc.subject.keywordPlus | RISK STRATIFICATION | - |
dc.subject.keywordPlus | MAGNETIC-RESONANCE | - |
dc.subject.keywordPlus | AMERICAN-COLLEGE | - |
dc.subject.keywordPlus | HEART-FAILURE | - |
dc.subject.keywordAuthor | hypertrophic cardiomyopathy | - |
dc.subject.keywordAuthor | strain | - |
dc.subject.keywordAuthor | sudden cardiac death | - |
dc.subject.keywordAuthor | heart failure | - |
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