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Preparation and Characterization of pH-Sensitive Capsosomes for Oral Delivery of Therapeutic Proteins
DC Field | Value | Language |
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dc.contributor.author | Yang, Eunhye | - |
dc.contributor.author | Jung, Ho -Sup | - |
dc.contributor.author | Chang, Pahn-Shick | - |
dc.date.accessioned | 2022-10-12T00:56:22Z | - |
dc.date.available | 2022-10-12T00:56:22Z | - |
dc.date.created | 2022-08-12 | - |
dc.date.issued | 2022-08 | - |
dc.identifier.citation | Langmuir, Vol.38 No.30, pp.9294-9300 | - |
dc.identifier.issn | 0743-7463 | - |
dc.identifier.uri | https://hdl.handle.net/10371/185932 | - |
dc.description.abstract | Oral administration of therapeutic proteins is very challenging because of gastrointestinal instability and decomposition. In this study, we developed a system for oral delivery of superoxide dismutase (SOD) as one of the therapeutic proteins. SOD-loaded capsosomes (SOD-C) were formed by the assembly of chitosan-coated solid lipid nanoparticles and SOD-loaded liposomes (SOD-L). Unlike raw SOD activity decreases to 19.41% in SGF and 13.70% in SIF, the SOD-C in SGF (89.30%) condition retained its initial catalytic activity and decreased but exhibited a three-fold higher raw SOD activity even after incubation in SIF (41.63%). TEM analysis indicated that after intestinal digestion, the residual amount of intact liposomes affected the higher catalytic activity of SOD-C compared to raw SOD and SOD-L. Based on these results, significantly higher cellular uptake of SOD-C was observed compared to raw SOD. Also, SOD-C remarkably suppressed the cellular malondialdehyde (MDA) concentration by maintaining the antioxidative capacity of SOD to remove MDA produced in the oxidative stress-induced cells, thereby contributing to a significant five-fold difference with SOD-R (p < 0.05). This delivery system can facilitate the oral application of other therapeutic proteins, improving gastrointestinal stability. | - |
dc.language | 영어 | - |
dc.publisher | American Chemical Society | - |
dc.title | Preparation and Characterization of pH-Sensitive Capsosomes for Oral Delivery of Therapeutic Proteins | - |
dc.type | Article | - |
dc.identifier.doi | 10.1021/acs.langmuir.2c01089 | - |
dc.citation.journaltitle | Langmuir | - |
dc.identifier.wosid | 000833001500001 | - |
dc.identifier.scopusid | 2-s2.0-85135500880 | - |
dc.citation.endpage | 9300 | - |
dc.citation.number | 30 | - |
dc.citation.startpage | 9294 | - |
dc.citation.volume | 38 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Chang, Pahn-Shick | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
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