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The Haemophilus influenzae HipBA toxin-antitoxin system adopts an unusual three-component regulatory mechanism
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Web of Science
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- Authors
- Issue Date
- 2022-09
- Publisher
- International Union of Crystallography
- Citation
- IUCrJ, Vol.9, pp.625-631
- Abstract
- Type II toxin-antitoxin (TA) systems encode two proteins: a toxin that inhibits cell growth and an antitoxin that neutralizes the toxin by direct intermolecular protein-protein interactions. The bacterial HipBA TA system is implicated in persister formation. The Haemophilus influenzae HipBATA system consists of a HipB antitoxin and a HipA toxin, the latter of which is split into two fragments, and here we investigate this novel three-component regulatory HipBA system. Structural and functional analysis revealed that HipA(N) corresponds to the N-terminal part of HipA from other bacteria and toxic HipA(C) is inactivated by HipA(N), not HipB. This study will be helpful in understanding the detailed regulatory mechanism of the HipBA(N+C) system, as well as why it is constructed as a three-component system.
- ISSN
- 2052-2525
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