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Differential influences of LDL cholesterol on functional outcomes after intravenous thrombolysis according to prestroke statin use
DC Field | Value | Language |
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dc.contributor.author | Kang, You-Ri | - |
dc.contributor.author | Kim, Joon-Tae | - |
dc.contributor.author | Lee, Ji Sung | - |
dc.contributor.author | Kim, Beom Joon | - |
dc.contributor.author | Kang, Kyusik | - |
dc.contributor.author | Lee, Soo Joo | - |
dc.contributor.author | Kim, Jae Guk | - |
dc.contributor.author | Cha, Jae-Kwan | - |
dc.contributor.author | Kim, Dae-Hyun | - |
dc.contributor.author | Park, Tai Hwan | - |
dc.contributor.author | Lee, Kyung Bok | - |
dc.contributor.author | Lee, Jun | - |
dc.contributor.author | Hong, Keun-Sik | - |
dc.contributor.author | Cho, Yong-Jin | - |
dc.contributor.author | Park, Hong-Kyun | - |
dc.contributor.author | Lee, Byung-Chul | - |
dc.contributor.author | Yu, Kyung-Ho | - |
dc.contributor.author | Oh, Mi Sun | - |
dc.contributor.author | Kim, Dong-Eog | - |
dc.contributor.author | Ryu, Wi-Sun | - |
dc.contributor.author | Choi, Jay Chol | - |
dc.contributor.author | Kwon, Jee-Hyun | - |
dc.contributor.author | Kim, Wook-Joo | - |
dc.contributor.author | Shin, Dong-Ick | - |
dc.contributor.author | Sohn, Sung Il | - |
dc.contributor.author | Hong, Jeong-Ho | - |
dc.contributor.author | Park, Man-Seok | - |
dc.contributor.author | Choi, Kang-Ho | - |
dc.contributor.author | Cho, Ki-Hyun | - |
dc.contributor.author | Park, Jong-Moo | - |
dc.contributor.author | Lee, Sang-Hwa | - |
dc.contributor.author | Lee, Juneyoung | - |
dc.contributor.author | Bae, Hee-Joon | - |
dc.date.accessioned | 2022-10-20T02:26:17Z | - |
dc.date.available | 2022-10-20T02:26:17Z | - |
dc.date.created | 2022-10-07 | - |
dc.date.issued | 2022-09 | - |
dc.identifier.citation | Scientific Reports, Vol.12 No.1, p. 15478 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | https://hdl.handle.net/10371/186556 | - |
dc.description.abstract | This study aimed to elucidate whether low-density lipoprotein cholesterol (LDL-C) levels differentially affect functional outcomes after intravenous thrombolysis (IVT) depending on prestroke statin use. Patients with acute ischemic stroke treated with IVT were categorized into low, intermediate, and high LDL-C groups based on LDL-C levels at admission (< 100/100-130/ > 130 mg/dl, respectively). Multivariable logistic regression analyses were performed to explore the relationships between LDL-C and clinical outcomes (good outcomes at 3 months, modified Rankin Scale scores 0-2). The interaction between LDL-C levels and prestroke statin use regarding functional outcomes was investigated. Among the 4711 patients (age, 67 +/- 12 years; males, 62.1%) who met the eligibility criteria, compared with the high LDL-C group, the low and intermediate LDL-C groups were not associated with good outcomes at 3 months according to the multivariable analysis. A potential interaction between the LDL-C group and prestroke statin use on good outcomes at 3 months was observed (P-interaction = 0.07). Among patients with prestroke statin use, low (aOR 1.84 [1.04- 3.26]) and intermediate (aOR 2.31 [1.20-4.47]) LDL-C groups were independently associated with a greater likelihood of having a 3-month good outcome. Our study showed that LDL-C was not associated with a 3-month good outcome, but prestroke statin use could modify the influence of LDL-C levels on functional outcomes after IVT. | - |
dc.language | 영어 | - |
dc.publisher | Nature Publishing Group | - |
dc.title | Differential influences of LDL cholesterol on functional outcomes after intravenous thrombolysis according to prestroke statin use | - |
dc.type | Article | - |
dc.identifier.doi | 10.1038/s41598-022-19852-8 | - |
dc.citation.journaltitle | Scientific Reports | - |
dc.identifier.wosid | 000853934100013 | - |
dc.identifier.scopusid | 2-s2.0-85137853489 | - |
dc.citation.number | 1 | - |
dc.citation.startpage | 15478 | - |
dc.citation.volume | 12 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Bae, Hee-Joon | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
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