Publications
Detailed Information
Association of metabolic comorbidity with myocardial infarction in individuals with a family history of cardiovascular disease: a prospective cohort study
DC Field | Value | Language |
---|---|---|
dc.contributor.author | An, Seokyung | - |
dc.contributor.author | Moon, Sungji | - |
dc.contributor.author | Park, Sue K. | - |
dc.date.accessioned | 2022-12-22T01:24:10Z | - |
dc.date.available | 2022-12-22T10:25:09Z | - |
dc.date.issued | 2022-10-31 | - |
dc.identifier.citation | BMC Public Health. 2022 Oct 31;22(1):1992 | ko_KR |
dc.identifier.issn | 1471-2458 | - |
dc.identifier.uri | https://doi.org/10.1186/s12889-022-14330-2 | - |
dc.identifier.uri | https://hdl.handle.net/10371/187335 | - |
dc.description.abstract | Background
The association between metabolic comorbidity and myocardial infarction (MI) among individuals with a family history of cardiovascular disease (CVD) is yet to be elucidated. We aimed to examine the combined effects of metabolic comorbidities, including diabetes mellitus, hypertension, and dyslipidemia, with a family history of CVD in first-degree on the risk of incident MI. Methods This cohort study consisted of 81,803 participants aged 40–89 years without a previous history of MI at baseline from the Korean Genome and Epidemiology Study. We performed Cox proportional hazard regression analysis to estimate the hazard ratios (HRs) and 95% confidence intervals (CIs) for MI and early-onset MI risk associated with metabolic comorbidity in individuals with a family history of CVD. Results During a median follow-up of 5 years, 1,075 and 479 cases of total and early-onset MI were reported, respectively. According to the disease score, among individuals who had a positive family history of CVD, the HRs for MI were 1.92 (95% CI: 1.47–2.51) in individuals with one disease, 2.75 (95% CI: 2.09–3.61) in those with two diseases, and 3.74 (95% CI: 2.45–5.71) in those with three diseases at baseline compared to individuals without a family history of CVD and metabolic diseases. Similarly, an increase of the disease score among individuals with a positive family history of CVD was associated with an increase in early-onset MI risk. Conclusion Metabolic comorbidity was significantly associated with an increased risk of MI among individuals with a family history of CVD. | ko_KR |
dc.description.sponsorship | This research was funded by a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (grant number: HI16C1127). | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | BMC | ko_KR |
dc.subject | Family history of cardiovascular disease | - |
dc.subject | Diabetes mellitus | - |
dc.subject | Hypertension | - |
dc.subject | Dyslipidemia | - |
dc.subject | Comorbidity | - |
dc.subject | Myocardial infarction | - |
dc.title | Association of metabolic comorbidity with myocardial infarction in individuals with a family history of cardiovascular disease: a prospective cohort study | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 안서경 | - |
dc.contributor.AlternativeAuthor | 문성지 | - |
dc.identifier.doi | 10.1186/s12889-022-14330-2 | ko_KR |
dc.citation.journaltitle | BMC Public Health | ko_KR |
dc.language.rfc3066 | en | - |
dc.rights.holder | The Author(s) | - |
dc.date.updated | 2022-11-06T04:14:37Z | - |
dc.citation.number | 1 | ko_KR |
dc.citation.startpage | 1992 | ko_KR |
dc.citation.volume | 22 | ko_KR |
- Appears in Collections:
- Files in This Item:
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.