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Heliciopsides A−E, Unusual Macrocyclic and Phenolic Glycosides from the Leaves of Heliciopsis terminalis and Their Stimulation of Glucose Uptake : Heliciopsides A-E, Unusual Macrocyclic and Phenolic Glycosides from the Leaves of Heliciopsis terminalis and Their Stimulation of Glucose Uptake
DC Field | Value | Language |
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dc.contributor.author | Ryu, Byeol | - |
dc.contributor.author | Park, Eun-Jin | - |
dc.contributor.author | Doan, Thi-Phuong | - |
dc.contributor.author | Cho, Hyo-Moon | - |
dc.contributor.author | An, Jin-Pyo | - |
dc.contributor.author | Pham, Thi-Linh-Giang | - |
dc.contributor.author | Pham, Ha-Thanh-Tung | - |
dc.contributor.author | Oh, Won Keun | - |
dc.date.accessioned | 2023-01-02T08:01:47Z | - |
dc.date.available | 2023-01-02T08:01:47Z | - |
dc.date.created | 2022-12-13 | - |
dc.date.issued | 2022-11 | - |
dc.identifier.citation | Pharmaceuticals, Vol.15 No.11, p. 1315 | - |
dc.identifier.issn | 1424-8247 | - |
dc.identifier.uri | https://hdl.handle.net/10371/188775 | - |
dc.description.abstract | Ten phenolic constituents, including three new macrocyclic glycosides (1-3), a new phenolic glycoside (5), a new biphenyl glycoside (6), and five known compounds (4, 7-10), were isolated from a 70% MeOH extract of the leaves of Heliciopsis terminalis by liquid chromatography-tandem mass spectrometry (LC-MS/MS)-guided molecular networking. The chemical structures of new compounds 1-3, 5 and 6 were established based on comprehensive spectroscopic data analysis, including 1D and 2D NMR and HRESIMS techniques. All isolated compounds (1-10) were evaluated for their stimulation of glucose uptake in differentiated 3T3-L1 adipocytes using 2-deoxy-2-[(7-nitro-2,1,3-benzoxadiazol-4-yl)amino]-D-glucose (2-NBDG) as a fluorescent glucose analog. Compounds 3, 6 and 8 showed stimulatory effects on the uptake of 2-NBDG in 3T3-L1 adipocyte cells. Among them, compounds 3 and 6 activated the AMPK signaling pathway in differentiated C2C12 myoblasts. | - |
dc.language | 영어 | - |
dc.publisher | Multidisciplinary Digital Publishing Institute (MDPI) | - |
dc.title | Heliciopsides A−E, Unusual Macrocyclic and Phenolic Glycosides from the Leaves of Heliciopsis terminalis and Their Stimulation of Glucose Uptake | - |
dc.title.alternative | Heliciopsides A-E, Unusual Macrocyclic and Phenolic Glycosides from the Leaves of Heliciopsis terminalis and Their Stimulation of Glucose Uptake | - |
dc.type | Article | - |
dc.identifier.doi | 10.3390/ph15111315 | - |
dc.citation.journaltitle | Pharmaceuticals | - |
dc.identifier.wosid | 000883961900001 | - |
dc.citation.number | 11 | - |
dc.citation.startpage | 1315 | - |
dc.citation.volume | 15 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Oh, Won Keun | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
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