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Pharmacological inhibition of Kv3 on oxidative stress-induced cataract progression
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Song, Min Seok | - |
dc.contributor.author | Sim, Hun Ju | - |
dc.contributor.author | Park, Sangwan | - |
dc.contributor.author | Seo, Kangmoon | - |
dc.contributor.author | Lee, So Yeong | - |
dc.date.accessioned | 2023-03-21T00:40:06Z | - |
dc.date.available | 2023-03-21T00:40:06Z | - |
dc.date.created | 2021-02-08 | - |
dc.date.created | 2021-02-08 | - |
dc.date.issued | 2020-12 | - |
dc.identifier.citation | Biochemical and Biophysical Research Communications, Vol.533 No.4, pp.1255-1261 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.uri | https://hdl.handle.net/10371/189722 | - |
dc.description.abstract | Oxidative stress is one of the most important risk factors for cataractogenesis. Previous studies have indicated that BDS-II, a Kv3 channel blocker, plays pivotal roles in oxidative stress-related diseases. This study demonstrates that BDS-II exerts a protective effect on cataractogenesis. Specifically, BDS-II was observed to inhibit lens opacity induced by H2O2. BDS-II was also determined to inhibit cataract progression in a sodium selenite-induced in vivo cataract model by inhibiting reduction of the total GSH. In addition, BDS-II was demonstrated to protect human lens epithelial cells against H2O2-induced cell death. Our results suggest that BDS-II is a potential pharmacological candidate in cataract therapy. | - |
dc.language | 영어 | - |
dc.publisher | Academic Press | - |
dc.title | Pharmacological inhibition of Kv3 on oxidative stress-induced cataract progression | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.bbrc.2020.09.138 | - |
dc.citation.journaltitle | Biochemical and Biophysical Research Communications | - |
dc.identifier.wosid | 000599719400023 | - |
dc.identifier.scopusid | 2-s2.0-85092502570 | - |
dc.citation.endpage | 1261 | - |
dc.citation.number | 4 | - |
dc.citation.startpage | 1255 | - |
dc.citation.volume | 533 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Seo, Kangmoon | - |
dc.contributor.affiliatedAuthor | Lee, So Yeong | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | SELENITE-INDUCED CATARACT | - |
dc.subject.keywordPlus | H2O2-INDUCED CATARACT | - |
dc.subject.keywordPlus | POTASSIUM CHANNELS | - |
dc.subject.keywordPlus | LENS | - |
dc.subject.keywordPlus | PREVENTS | - |
dc.subject.keywordPlus | ACID | - |
dc.subject.keywordPlus | MODULATION | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordAuthor | Cataract | - |
dc.subject.keywordAuthor | Cataractogenesis | - |
dc.subject.keywordAuthor | Oxidative stress | - |
dc.subject.keywordAuthor | BDS-II | - |
dc.subject.keywordAuthor | Kv3 | - |
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