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Sustained Delivery of Carfilzomib by Tannic Acid-Based Nanocapsules Helps Develop Antitumor Immunity
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Taha, Maie S. | - |
dc.contributor.author | Cresswell, Gregory M. | - |
dc.contributor.author | Park, Joonyoung | - |
dc.contributor.author | Lee, Wooin | - |
dc.contributor.author | Ratliff, Timothy L. | - |
dc.contributor.author | Yeo, Yoon | - |
dc.date.accessioned | 2023-04-18T06:24:34Z | - |
dc.date.available | 2023-04-18T06:24:34Z | - |
dc.date.created | 2020-01-16 | - |
dc.date.issued | 2019-11 | - |
dc.identifier.citation | Nano Letters, Vol.19 No.11, pp.8333-8341 | - |
dc.identifier.issn | 1530-6984 | - |
dc.identifier.uri | https://hdl.handle.net/10371/190100 | - |
dc.description.abstract | A group of chemotherapeutic drugs has gained increasing interest in cancer immunotherapy due to the potential to induce immunogenic cell death (ICD). A critical challenge in using the ICD inducers in cancer immunotherapy is the immunotoxicity accompanying their antiproliferative effects. To alleviate this, a nanocapsule formulation of carfilzomib (CFZ), an ICD-inducing proteasome inhibitor, was developed using interfacial supramolecular assembly of tannic acid (TA) and iron, supplemented with albumin coating. The albumin-coated CFZ nanocapsules (CFZ-pTA-alb) attenuated CFZ release, reducing toxicity to immune cells. Moreover, due to the adhesive nature of the TA assembly, CFZ-pTA-alb served as a reservoir of damage-associated molecular patterns released from dying tumor cells to activate dendritic cells. Upon intratumoral administration, CFZ-pTA-alb prolonged tumor retention of CFZ and showed consistently greater antitumor effects than cyclodextrin-solubilized CFZ (CFZ-CD) in B16F10 and CT26 tumor models. Unlike CFZ-CD, the locally injected CFZ-pTA-alb protected or enhanced CD8(+) T cell population in tumors, helped develop splenocytes with tumor-specific interferon-gamma response, and delayed tumor development on the contralateral side in immunocompetent mice (but not in athymic nude mice), supporting that CFZ-pTA-alb contributed to activating antitumor immunity. This study demonstrates that sustained delivery of ICD inducers by TA-based nanocapsules is an effective way of translating local ICD induction to systemic antitumor immunity. | - |
dc.language | 영어 | - |
dc.publisher | American Chemical Society | - |
dc.title | Sustained Delivery of Carfilzomib by Tannic Acid-Based Nanocapsules Helps Develop Antitumor Immunity | - |
dc.type | Article | - |
dc.identifier.doi | 10.1021/acs.nanolett.9b04147 | - |
dc.citation.journaltitle | Nano Letters | - |
dc.identifier.wosid | 000497259300092 | - |
dc.identifier.scopusid | 2-s2.0-85074631072 | - |
dc.citation.endpage | 8341 | - |
dc.citation.number | 11 | - |
dc.citation.startpage | 8333 | - |
dc.citation.volume | 19 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Lee, Wooin | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | REGULATORY T-CELLS | - |
dc.subject.keywordPlus | P-GLYCOPROTEIN | - |
dc.subject.keywordPlus | MULTIPLE-MYELOMA | - |
dc.subject.keywordPlus | DOSE THERAPY | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | CHEMOTHERAPY | - |
dc.subject.keywordPlus | ANTIGEN | - |
dc.subject.keywordPlus | IMMUNOGENICITY | - |
dc.subject.keywordPlus | NANOPARTICLES | - |
dc.subject.keywordPlus | RESISTANCE | - |
dc.subject.keywordAuthor | Immunogenic cell death | - |
dc.subject.keywordAuthor | carfilzomib | - |
dc.subject.keywordAuthor | nanocapsules | - |
dc.subject.keywordAuthor | tannic acid | - |
dc.subject.keywordAuthor | sustained release | - |
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