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Role of dietary curcumin against waterborne lead toxicity in common carp Cyprinus carpio
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Giri, Sib Sankar | - |
dc.contributor.author | Kim, Min Jung | - |
dc.contributor.author | Kim, Sang Guen | - |
dc.contributor.author | Kim, Sang Wha | - |
dc.contributor.author | Kang, Jeong Woo | - |
dc.contributor.author | Kwon, Jun | - |
dc.contributor.author | Lee, Sung Bin | - |
dc.contributor.author | Jung, Won Joon | - |
dc.contributor.author | Sukumaran, Venkatachalam | - |
dc.contributor.author | Park, Se Chang | - |
dc.date.accessioned | 2023-04-19T01:08:03Z | - |
dc.date.available | 2023-04-19T01:08:03Z | - |
dc.date.created | 2021-07-07 | - |
dc.date.created | 2021-07-07 | - |
dc.date.created | 2021-07-07 | - |
dc.date.created | 2021-07-07 | - |
dc.date.created | 2021-07-07 | - |
dc.date.created | 2021-07-07 | - |
dc.date.created | 2021-07-07 | - |
dc.date.issued | 2021-08 | - |
dc.identifier.citation | Ecotoxicology and Environmental Safety, Vol.219, p. 112318 | - |
dc.identifier.issn | 0147-6513 | - |
dc.identifier.uri | https://hdl.handle.net/10371/190411 | - |
dc.description.abstract | Curcumin exhibited numerous key activities including antioxidant, anti-inflammatory, and immunostimulatory effects in fish. This study evaluated the protective effects of curcumin (CUR) against lead (Pb)-induced toxicities in fish. Healthy Cyprinus carpio L. individuals were segregated into control, Pb only, Pb+CUR, and CUR only groups. Pb groups were exposed to 1 mg L -1 of Pb, and CUR groups were fed a basal diet supplemented with 15 g kg 1 of CUR. After eight weeks, growth performance, Pb accumulation in tissues, various haemato-biochemical parameters, immune responses, and cytokine gene expression were measured. Dietary CUR effectively decreased Pb accumulation in tissues and increased the survival of Pb-exposed fish. Co-treatment with Pb and CUR reversed alterations in haemato-biochemical parameters, ameliorated Pb-induced oxidative stress, enhanced immune responses, and restored intestinal enzymatic activities. Dietary CUR reversed changes in intestinal microbiota in Pb-exposed fish. Pb-induced upregulation of NF-kappa Bp65 and HSP70 was inhibited by dietary CUR. CUR supplementation upregulated the mRNA levels of SOD, Nrf2, IL-10, and CYP450 1A and attenuated Pb-induced degradation of I kappa B-alpha mRNA levels. Overall, CUR antagonizes Pb-induced negative impacts in fish. Thus, dietary CUR had several beneficial effects on immune responses, decreased Pb accumulation in tissues, and reversed Pb-induced oxidative stress in fish. Therefore, CUR plays a protective role in Pb-induced immune toxicity in fish, and, as such, may be suitable as an aqua feed additive for use in carp aquaculture. | - |
dc.language | 영어 | - |
dc.publisher | Academic Press | - |
dc.title | Role of dietary curcumin against waterborne lead toxicity in common carp Cyprinus carpio | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.ecoenv.2021.112318 | - |
dc.citation.journaltitle | Ecotoxicology and Environmental Safety | - |
dc.identifier.wosid | 000663585400009 | - |
dc.identifier.scopusid | 2-s2.0-85105589181 | - |
dc.citation.startpage | 112318 | - |
dc.citation.volume | 219 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Park, Se Chang | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | GROWTH-PERFORMANCE | - |
dc.subject.keywordPlus | CADMIUM | - |
dc.subject.keywordPlus | SUPPLEMENTATION | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | RESISTANCE | - |
dc.subject.keywordPlus | IMMUNITY | - |
dc.subject.keywordPlus | STRESS | - |
dc.subject.keywordPlus | POWDER | - |
dc.subject.keywordAuthor | Heavy metal | - |
dc.subject.keywordAuthor | Oxidative stress | - |
dc.subject.keywordAuthor | Gene expression | - |
dc.subject.keywordAuthor | Hepatotoxicity | - |
dc.subject.keywordAuthor | Antioxidant enzymes | - |
dc.subject.keywordAuthor | Hepatosomatic index | - |
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