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Effects of porous beta-tricalcium phosphate-based ceramics used as an E-coli-derived rhBMP-2 carrier for bone regeneration
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Jae Hyup | - |
dc.contributor.author | Ryu, Mi Young | - |
dc.contributor.author | Baek, Hae-Ri | - |
dc.contributor.author | Lee, Kyung Mee | - |
dc.contributor.author | Seo, Jun-Hyuk | - |
dc.contributor.author | Lee, Hyun-Kyung | - |
dc.contributor.author | Ryu, Hyun-Seung | - |
dc.date.accessioned | 2023-04-19T07:11:27Z | - |
dc.date.available | 2023-04-19T07:11:27Z | - |
dc.date.created | 2021-05-03 | - |
dc.date.issued | 2013-09 | - |
dc.identifier.citation | Journal of Materials Science: Materials in Medicine, Vol.24 No.9, pp.2117-2127 | - |
dc.identifier.issn | 0957-4530 | - |
dc.identifier.uri | https://hdl.handle.net/10371/190855 | - |
dc.description.abstract | Recombinant human bone morphogenetic protein-2 (rhBMP-2) requires carriers for clinical effectiveness. In this study, whether porous beta-tricalcium phosphate (beta-TCP)-based ceramics are ideal carriers for rhBMP-2 was investigated. Hydroxyapatite (HA), beta-TCP, TCP/HA (80 %/20 %), HA with rhBMP-2, TCP with rhBMP-2, and TCP/HA (80 %/20 %) with rhBMP-2 were manufactured by a sponge method with a pore size of 300 mu m or more and macro-porosity of 83 %. The alkaline phosphatase (ALP) activity and ALP expression of the cells with 100 % beta-TCP granules were more increased than the those of cells with 100 % HA and TCP/HA (80 %/20 %) at the baseline or when treated with 15 ng/ml of rhBMP-2. In an SD rat calvarial defect model, new bone formation was evidently shown in the TCP 100 %-rhBMP-2 and TCP/HA (80 %/20 %)-rhBMP-2 groups, showing that the most affected area was filled with newly-formed bone, that the percent bone volume and trabecular number were larger when compared to the groups without rhBMP-2 treatment at both 4 and 8 weeks after surgery using micro-CT and histology. Porous TCP-based ceramic granules enhanced the osteoblastic differentiation in the hMSC system when treated with 15 ng/ml of rhBMP-2 and accelerated bone-healing by trabecular number in a rat calvarial defect model. Thus, in this study it was proposed that TCP-based ceramics might be useful carriers of rhBMP-2. | - |
dc.language | 영어 | - |
dc.publisher | Kluwer Academic Publishers | - |
dc.title | Effects of porous beta-tricalcium phosphate-based ceramics used as an E-coli-derived rhBMP-2 carrier for bone regeneration | - |
dc.type | Article | - |
dc.identifier.doi | 10.1007/s10856-013-4967-5 | - |
dc.citation.journaltitle | Journal of Materials Science: Materials in Medicine | - |
dc.identifier.wosid | 000323289600004 | - |
dc.identifier.scopusid | 2-s2.0-84884289166 | - |
dc.citation.endpage | 2127 | - |
dc.citation.number | 9 | - |
dc.citation.startpage | 2117 | - |
dc.citation.volume | 24 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Lee, Jae Hyup | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | MORPHOGENETIC PROTEIN-2 | - |
dc.subject.keywordPlus | ESCHERICHIA-COLI | - |
dc.subject.keywordPlus | BMP-2 | - |
dc.subject.keywordPlus | MODEL | - |
dc.subject.keywordPlus | PURIFICATION | - |
dc.subject.keywordPlus | EFFICACY | - |
dc.subject.keywordPlus | DEFECTS | - |
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