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Long-term oncological and functional outcomes of induction chemotherapy followed by (chemo)radiotherapy vs definitive chemoradiotherapy vs surgery-based therapy in locally advanced stage III/IV hypopharyngeal cancer: Multicenter review of 266 cases
DC Field | Value | Language |
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dc.contributor.author | Chung, Eun-Jae | - |
dc.contributor.author | Jeong, Woo-Jin | - |
dc.contributor.author | Jung, Young Ho | - |
dc.contributor.author | Kwon, Seong Keun | - |
dc.contributor.author | Kwon, Tack-Kyun | - |
dc.contributor.author | Ahn, Soon-Hyun | - |
dc.contributor.author | Sung, Myung-Whun | - |
dc.contributor.author | Keam, Bhumsuk | - |
dc.contributor.author | Heo, Dae-Seog | - |
dc.contributor.author | Kim, Jin Ho | - |
dc.contributor.author | Wu, Hong-Gyun | - |
dc.contributor.author | Lee, Keun-Wook | - |
dc.contributor.author | Eom, Keun-Yong | - |
dc.contributor.author | Rho, Young-Soo | - |
dc.date.accessioned | 2023-04-20T01:26:28Z | - |
dc.date.available | 2023-04-20T01:26:28Z | - |
dc.date.created | 2019-11-29 | - |
dc.date.issued | 2019-02 | - |
dc.identifier.citation | Oral Oncology, Vol.89, pp.84-94 | - |
dc.identifier.issn | 1368-8375 | - |
dc.identifier.uri | https://hdl.handle.net/10371/191304 | - |
dc.description.abstract | Objective: The aim of this study was to evaluate the treatment outcomes for stage III/IV locally advanced hypopharyngeal squamous cell carcinoma (SCC), comparing induction chemotherapy followed by (chemo) radiotherapy (ICT), definitive chemoradiotherapy (CRT) and surgery-based therapy (SRT). Subjects and Methods: Two hundred sixty-six patients with stage III/IV locally advanced hypopharyngeal squamous cell carcinoma (SCC) who underwent ICT (n = 74), CRT (n = 53) or SRT (n = 139) from 1997 through 2014 at the Seoul National University Hospital (n = 127) and the Hallym University Medical Center (n = 139) were enrolled in the study. All surgical procedures in the SRT group were performed by a single surgeon to eliminate surgeon bias. Results: The 5-year disease-free survival (DFS) and overall survival (OS) of all patients (n = 266) were 59.4% and 44%, respectively. The 5-year DFS rates after salvage treatment were 52.7% for ICT, 52.8% for CRT and 65.5% for SRT (p = 0.194). The OS rates were 44.6% for ICT, 39.6% for CRT and 45.3% for SRT group (p = 0.106). The salvage rates were 12.5% for ICT, 15.6% for CRT and 3.8% for SRT group. The final laryngeal preservation rate was significantly lower in the SRT group (44.6%) than in the ICT (71.6%) or CRT (71.7%) groups. All major postoperative complications were significantly higher in the salvage surgery group. Conclusion: Treatment outcomes in the ICT and CRT groups were comparable to that of the SRT group for stage III/IV hypopharyngeal SCC. However, the relatively low chance of cure and high risk of complications should be taken into account when considering salvage surgery. | - |
dc.language | 영어 | - |
dc.publisher | Pergamon Press Ltd. | - |
dc.title | Long-term oncological and functional outcomes of induction chemotherapy followed by (chemo)radiotherapy vs definitive chemoradiotherapy vs surgery-based therapy in locally advanced stage III/IV hypopharyngeal cancer: Multicenter review of 266 cases | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.oraloncology.2018.12.015 | - |
dc.citation.journaltitle | Oral Oncology | - |
dc.identifier.wosid | 000457569200014 | - |
dc.identifier.scopusid | 2-s2.0-85059061463 | - |
dc.citation.endpage | 94 | - |
dc.citation.startpage | 84 | - |
dc.citation.volume | 89 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Chung, Eun-Jae | - |
dc.contributor.affiliatedAuthor | Kwon, Seong Keun | - |
dc.contributor.affiliatedAuthor | Kwon, Tack-Kyun | - |
dc.contributor.affiliatedAuthor | Ahn, Soon-Hyun | - |
dc.contributor.affiliatedAuthor | Sung, Myung-Whun | - |
dc.contributor.affiliatedAuthor | Heo, Dae-Seog | - |
dc.contributor.affiliatedAuthor | Wu, Hong-Gyun | - |
dc.contributor.affiliatedAuthor | Lee, Keun-Wook | - |
dc.type.docType | Review | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | SQUAMOUS-CELL CARCINOMA | - |
dc.subject.keywordPlus | SALVAGE SURGERY | - |
dc.subject.keywordPlus | RADIOTHERAPY | - |
dc.subject.keywordPlus | LARYNX | - |
dc.subject.keywordPlus | PRESERVATION | - |
dc.subject.keywordPlus | HEAD | - |
dc.subject.keywordAuthor | Hypopharyngeal cancer | - |
dc.subject.keywordAuthor | Surgery | - |
dc.subject.keywordAuthor | Radiation therapy | - |
dc.subject.keywordAuthor | Chemotherapy | - |
dc.subject.keywordAuthor | Prognosis | - |
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