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Cross-talk between human mesenchymal stem/progenitor cells (MSCs) and rat hippocampal slices in LPS-stimulated cocultures: The MSCs are activated to secrete prostaglandin E2
DC Field | Value | Language |
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dc.contributor.author | Foraker, Jessica E. | - |
dc.contributor.author | Oh, Joo Youn | - |
dc.contributor.author | Ylostalo, Joni H. | - |
dc.contributor.author | Lee, Ryang Hwa | - |
dc.contributor.author | Watanabe, Jun | - |
dc.contributor.author | Prockop, Darwin J. | - |
dc.date.accessioned | 2023-04-28T06:57:29Z | - |
dc.date.available | 2023-04-28T06:57:29Z | - |
dc.date.created | 2023-04-26 | - |
dc.date.created | 2023-04-26 | - |
dc.date.issued | 2011-12 | - |
dc.identifier.citation | Journal of Neurochemistry, Vol.119 No.5, pp.1052-1063 | - |
dc.identifier.issn | 0022-3042 | - |
dc.identifier.uri | https://hdl.handle.net/10371/191729 | - |
dc.description.abstract | Mesenchymal stem/progenitor cells (MSCs) improve functional outcome in a number of disease models through suppression of inflammation. However, their effects on neuroinflammation are unknown. In this study, we show that MSCs suppress endotoxin-induced glial activation in organotypic hippocampal slice cultures (OHSCs). Lipopolysaccharide-stimulated OHSCs activated MSCs to increase the expression of cyclo-oxygenase-2 and produce prostaglandin E2. MSC-derived prostaglandin E2, then suppressed pro-inflammatory cytokine production by the OHSCs. Together, the results suggest the potential anti-inflammatory mechanism of MSCs in models of disease and support earlier observations that MSCs may offer a therapy for neuroinflammation produced by trauma or disease. © 2011 The Authors. Journal of Neurochemistry © 2011 International Society for Neurochemistry. | - |
dc.language | 영어 | - |
dc.publisher | Blackwell Publishing Inc. | - |
dc.title | Cross-talk between human mesenchymal stem/progenitor cells (MSCs) and rat hippocampal slices in LPS-stimulated cocultures: The MSCs are activated to secrete prostaglandin E2 | - |
dc.type | Article | - |
dc.identifier.doi | 10.1111/j.1471-4159.2011.07511.x | - |
dc.citation.journaltitle | Journal of Neurochemistry | - |
dc.identifier.wosid | 000297948000016 | - |
dc.identifier.scopusid | 2-s2.0-81255205272 | - |
dc.citation.endpage | 1063 | - |
dc.citation.number | 5 | - |
dc.citation.startpage | 1052 | - |
dc.citation.volume | 119 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Oh, Joo Youn | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordAuthor | cyclo-oxygenase-2 | - |
dc.subject.keywordAuthor | inflammation | - |
dc.subject.keywordAuthor | lipopolysaccharide | - |
dc.subject.keywordAuthor | OHSC | - |
dc.subject.keywordAuthor | organotypic | - |
dc.subject.keywordAuthor | PGE2 | - |
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