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Potential oncogenic role and prognostic implication of microRNA-155-5p in oral squamous cell carcinoma
DC Field | Value | Language |
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dc.contributor.author | Kim, Hyojin | - |
dc.contributor.author | Yang, Jeong Mi | - |
dc.contributor.author | Ahn, Soon-Hyun | - |
dc.contributor.author | Jeong, Woo-Jin | - |
dc.contributor.author | Chung, Jin-Haeng | - |
dc.contributor.author | Paik, Jin Ho | - |
dc.date.accessioned | 2023-05-08T00:35:55Z | - |
dc.date.available | 2023-05-08T00:35:55Z | - |
dc.date.created | 2019-06-25 | - |
dc.date.created | 2019-06-25 | - |
dc.date.issued | 2018-09 | - |
dc.identifier.citation | Anticancer Research, Vol.38 No.9, pp.5193-5200 | - |
dc.identifier.issn | 0250-7005 | - |
dc.identifier.uri | https://hdl.handle.net/10371/191929 | - |
dc.description.abstract | Background: Altered microRNA expression is associated with cancer progression. This study investigated the prognostic significance of microRNA-155-5p (miR-155-5p), a well-known oncomiR, in oral squamous cell carcinoma (OSCC). Materials and Methods: miR-155-5p expression was assessed using quantitative reverse-transcription polymerase chain reaction in 68 formalin-fixed, paraffin-embedded OSCC specimens. E-Cadherin immunohistochemistry was conducted to correlate epithelial-mesenchymal transition (EMT) with miR- 155-5p expression. Results: Elevated miR-155-5p was associated with higher pathological TNM stage (p=0.048) and relapse (p=0.029). High miR-155-5p expression, along with angiolymphatic invasion and advanced stage, was a statistically significant prognostic factor for poorer diseasefree survival. In patients with stage I-II disease, high miR-155-5p was the only significant prognostic factor (p=0.033). A significant negative correlation was observed between miR-155-5p and E-cadherin expression (p=0.015), suggesting a possible role for miR-155-5p in EMT. Conclusion: miR-155-5p expression might contribute to EMT-associated OSCC progression and serve as a biomarker for predicting relapse, especially for patients with early-stage OSCC. | - |
dc.language | 영어 | - |
dc.publisher | International Institute of Anticancer Research | - |
dc.title | Potential oncogenic role and prognostic implication of microRNA-155-5p in oral squamous cell carcinoma | - |
dc.type | Article | - |
dc.identifier.doi | 10.21873/anticanres.12842 | - |
dc.citation.journaltitle | Anticancer Research | - |
dc.identifier.wosid | 000449957600028 | - |
dc.identifier.scopusid | 2-s2.0-85053014987 | - |
dc.citation.endpage | 5200 | - |
dc.citation.number | 9 | - |
dc.citation.startpage | 5193 | - |
dc.citation.volume | 38 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Ahn, Soon-Hyun | - |
dc.contributor.affiliatedAuthor | Chung, Jin-Haeng | - |
dc.contributor.affiliatedAuthor | Paik, Jin Ho | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | EPITHELIAL-MESENCHYMAL TRANSITION | - |
dc.subject.keywordPlus | NF-KAPPA-B | - |
dc.subject.keywordPlus | HEPATOCELLULAR-CARCINOMA | - |
dc.subject.keywordPlus | BREAST-CANCER | - |
dc.subject.keywordPlus | E-CADHERIN | - |
dc.subject.keywordPlus | MIR-155 | - |
dc.subject.keywordPlus | PROMOTES | - |
dc.subject.keywordPlus | HEAD | - |
dc.subject.keywordPlus | METASTASIS | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordAuthor | Epithelial-mesenchymal transition | - |
dc.subject.keywordAuthor | microRNA | - |
dc.subject.keywordAuthor | miR-155 | - |
dc.subject.keywordAuthor | oral cancer | - |
dc.subject.keywordAuthor | relapse | - |
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