Publications
Detailed Information
Clinicopathologic implications of the miR-197/PD-L1 axis in oral squamous cell carcinoma
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ahn, Hyein | - |
dc.contributor.author | Yang, Jeong Mi | - |
dc.contributor.author | Kim, Hyojin | - |
dc.contributor.author | Chung, Jin-Haeng | - |
dc.contributor.author | Ahn, Soon-Hyun | - |
dc.contributor.author | Jeong, Woo-Jin | - |
dc.contributor.author | Paik, Jin Ho | - |
dc.date.accessioned | 2023-05-08T00:41:05Z | - |
dc.date.available | 2023-05-08T00:41:05Z | - |
dc.date.created | 2018-11-07 | - |
dc.date.created | 2018-11-07 | - |
dc.date.issued | 2017-09 | - |
dc.identifier.citation | Oncotarget, Vol.8 No.39, pp.66178-66194 | - |
dc.identifier.issn | 1949-2553 | - |
dc.identifier.uri | https://hdl.handle.net/10371/191952 | - |
dc.description.abstract | Immune escape of a tumor from tumor-infiltrating lymphocytes (TILs) is induced by PD-L1, which is suppressed by miR-197. We investigated the clinicopathologic implications of the miR-197/PD-L1 axis and its effects on TILs and the clinicopathologic features of oral squamous cell carcinoma (OSCC). We used RT-PCR and immunohistochemistry in 68 OSCC patients to analyze the correlations between tumoral expression of miR-197 and PD-L1 and the degree of tumoral invasion by TILs (CD3+, CD4+, CD8+, PD-1+, FoxP3+, and CD20+ lymphocytes). PD-L1 levels correlated inversely with miR-197 but correlated positively with TILs. The aggressive features of OSCC, including high stage, angiolymphatic invasion, perineural invasion, and death, were associated with TIL depletion. High T stage (T4) tumors also had low PD-L1 but had high miR-197 expression. In a univariate survival analysis of the full cohort, high miR-197 was associated with poor overall survival, whereas high PD-L1 expression (2+) associated with good overall survival. In a multivariate analysis stratified based on miR-197 (median), high PD-L1 expression (2+) was an independent favorable prognostic factor for overall survival (P = 0.040) in the miR-197(high) subgroup but not the miR-197(low) subgroup. These findings may have clinicopathologic implications for the miR-197/PD-L1 axis and TILs in OSCC. | - |
dc.language | 영어 | - |
dc.publisher | Impact Journals | - |
dc.title | Clinicopathologic implications of the miR-197/PD-L1 axis in oral squamous cell carcinoma | - |
dc.type | Article | - |
dc.identifier.doi | 10.18632/oncotarget.19842 | - |
dc.citation.journaltitle | Oncotarget | - |
dc.identifier.wosid | 000410291200121 | - |
dc.identifier.scopusid | 2-s2.0-85030112057 | - |
dc.citation.endpage | 66194 | - |
dc.citation.number | 39 | - |
dc.citation.startpage | 66178 | - |
dc.citation.volume | 8 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Chung, Jin-Haeng | - |
dc.contributor.affiliatedAuthor | Ahn, Soon-Hyun | - |
dc.contributor.affiliatedAuthor | Paik, Jin Ho | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | TUMOR-INFILTRATING LYMPHOCYTES | - |
dc.subject.keywordPlus | PD-L1 EXPRESSION | - |
dc.subject.keywordPlus | PROGNOSTIC IMPLICATIONS | - |
dc.subject.keywordPlus | IFN-GAMMA | - |
dc.subject.keywordPlus | OVEREXPRESSION | - |
dc.subject.keywordPlus | SUPPRESSOR | - |
dc.subject.keywordPlus | RELEVANCE | - |
dc.subject.keywordPlus | HEAD | - |
dc.subject.keywordPlus | P27 | - |
dc.subject.keywordAuthor | PD-L1 | - |
dc.subject.keywordAuthor | oral squamous cell carcinoma | - |
dc.subject.keywordAuthor | miR-197 | - |
dc.subject.keywordAuthor | microRNA | - |
dc.subject.keywordAuthor | tumor-infiltrating lymphocytes | - |
- Appears in Collections:
- Files in This Item:
- There are no files associated with this item.
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.