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An increase of M2 macrophages predicts poor prognosis in patients with diffuse large B-cell lymphoma treated with rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone
DC Field | Value | Language |
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dc.contributor.author | Nam, Soo Jeong | - |
dc.contributor.author | Go, Heounjeong | - |
dc.contributor.author | Paik, Jin Ho | - |
dc.contributor.author | Kim, Tae Min | - |
dc.contributor.author | Heo, Dae Seog | - |
dc.contributor.author | Kim, Chul Woo | - |
dc.contributor.author | Jeon, Yoon Kyung | - |
dc.date.accessioned | 2023-05-08T00:44:37Z | - |
dc.date.available | 2023-05-08T00:44:37Z | - |
dc.date.created | 2021-01-05 | - |
dc.date.created | 2021-01-05 | - |
dc.date.issued | 2014-11 | - |
dc.identifier.citation | Leukemia and Lymphoma, Vol.55 No.11, pp.2466-2476 | - |
dc.identifier.issn | 1042-8194 | - |
dc.identifier.uri | https://hdl.handle.net/10371/192023 | - |
dc.description.abstract | Tumor-associated macrophages (TAMs) and regulatory T-cells (Tregs) play an important role in the tumor microenvironment. Here, we investigated the prognostic implications of TAMs and Tregs in 165 diffuse large B-cell lymphomas (DLBCLs) using immunohistochemistry. Survival analysis was performed among 109 DLBCLs treated with rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone (R-CHOP). An increase in CD68 (+) cells was related to improved overall survival (OS) (p = 0.033). By contrast, an increased number of CD163 (+) cells and a higher ratio of CD163/CD68 (+) cells were significantly associated with shorter OS (p = 0.041 and 0.003) and progression-free survival (PFS) (p < 0.001 and 0.002). Patients with increased Tregs tended to have a better prognosis. In multivariate analysis, an increased ratio of CD163/CD68 (+) cells was an independent predictor of shorter OS and PFS. These results suggest that M2 macrophages might have a lymphoma-promoting function in DLBCL and predict poor clinical outcome. Therapeutic approaches targeting M2 macrophages would be valuable for the management of DLBCL in the R era. | - |
dc.language | 영어 | - |
dc.publisher | Taylor & Francis | - |
dc.title | An increase of M2 macrophages predicts poor prognosis in patients with diffuse large B-cell lymphoma treated with rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone | - |
dc.type | Article | - |
dc.identifier.doi | 10.3109/10428194.2013.879713 | - |
dc.citation.journaltitle | Leukemia and Lymphoma | - |
dc.identifier.wosid | 000344339000010 | - |
dc.identifier.scopusid | 2-s2.0-84912123889 | - |
dc.citation.endpage | 2476 | - |
dc.citation.number | 11 | - |
dc.citation.startpage | 2466 | - |
dc.citation.volume | 55 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Paik, Jin Ho | - |
dc.contributor.affiliatedAuthor | Heo, Dae Seog | - |
dc.contributor.affiliatedAuthor | Kim, Chul Woo | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | TUMOR-ASSOCIATED MACROPHAGES | - |
dc.subject.keywordPlus | REGULATORY T-CELLS | - |
dc.subject.keywordPlus | CLASSICAL HODGKINS LYMPHOMA | - |
dc.subject.keywordPlus | FOLLICULAR LYMPHOMA | - |
dc.subject.keywordPlus | HIGH NUMBERS | - |
dc.subject.keywordPlus | INDEPENDENT PREDICTOR | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | SURVIVAL | - |
dc.subject.keywordPlus | CORRELATE | - |
dc.subject.keywordPlus | SUBTYPES | - |
dc.subject.keywordAuthor | Tumor microenvironment | - |
dc.subject.keywordAuthor | tumor-associated macrophages | - |
dc.subject.keywordAuthor | M2 macrophages | - |
dc.subject.keywordAuthor | diffuse large B-cell lymphoma | - |
dc.subject.keywordAuthor | regulatory T-cells | - |
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