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Clinicopathologic implication of A20/TNFAIP3 deletion in diffuse large B-cell lymphoma: an analysis according to immunohistochemical subgroups and rituximab treatment
DC Field | Value | Language |
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dc.contributor.author | Paik, Jin Ho | - |
dc.contributor.author | Go, Heounjeong | - |
dc.contributor.author | Nam, Soo Jeong | - |
dc.contributor.author | Kim, Tae Min | - |
dc.contributor.author | Heo, Dae Seog | - |
dc.contributor.author | Kim, Chul-Woo | - |
dc.contributor.author | Jeon, Yoon Kyung | - |
dc.date.accessioned | 2023-05-08T00:49:18Z | - |
dc.date.available | 2023-05-08T00:49:18Z | - |
dc.date.created | 2021-05-03 | - |
dc.date.created | 2021-05-03 | - |
dc.date.issued | 2013-09 | - |
dc.identifier.citation | Leukemia and Lymphoma, Vol.54 No.9, pp.1934-1941 | - |
dc.identifier.issn | 1042-8194 | - |
dc.identifier.uri | https://hdl.handle.net/10371/192061 | - |
dc.description.abstract | We analyzed the clinicopathologic implication of A20/tumor necrosis factor alpha-induced protein 3 deletion in diffuse large B-cell lymphoma (DLBCL) using fluorescence in situ hybridization, according to germinal center B-cell (GCB) versus non-GCB/activated B-cell (ABC) phenotypes and rituximab treatment. Excluding primary central nervous system (CNS) and Epstein-Barr virus (EBV)-positive lymphomas, 134 DLBCLs were analyzed. A20 was deleted in 23.1% (31/134) of DLBCLs including 21.6% (29/134) of monoallelic and 1.5% (2/134) of biallelic deletion, with no predilection for GCB versus non-GCB/ABC. In univariate analysis, A20 deletion was marginally associated with favorable prognosis in the rituximab-treated subgroup (n = 109; p = 0.0454), non-gastrointestinal lymphoma (n = 108; p = 0.0320) and nodal lymphoma (n = 46; p = 0.0411). In multivariate analysis in rituximab-treated DLBCL, MUM1 and international prognostic index (IPI) were independent prognostic factors (p = 0.021 [IPI]; p = 009 [MUM1]) with a marginally favorable prognostic effect for A20 deletion (p = 0.047). Taken together, A20 deletion was observed in similar frequencies in GCB and non-GCB/ABC, and was not a poor prognostic factor in DLBCL. | - |
dc.language | 영어 | - |
dc.publisher | Taylor & Francis | - |
dc.title | Clinicopathologic implication of A20/TNFAIP3 deletion in diffuse large B-cell lymphoma: an analysis according to immunohistochemical subgroups and rituximab treatment | - |
dc.type | Article | - |
dc.identifier.doi | 10.3109/10428194.2012.762511 | - |
dc.citation.journaltitle | Leukemia and Lymphoma | - |
dc.identifier.wosid | 000323492400015 | - |
dc.identifier.scopusid | 2-s2.0-84882943387 | - |
dc.citation.endpage | 1941 | - |
dc.citation.number | 9 | - |
dc.citation.startpage | 1934 | - |
dc.citation.volume | 54 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Paik, Jin Ho | - |
dc.contributor.affiliatedAuthor | Heo, Dae Seog | - |
dc.contributor.affiliatedAuthor | Kim, Chul-Woo | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | COMPARATIVE GENOMIC HYBRIDIZATION | - |
dc.subject.keywordPlus | CHROMOSOMAL IMBALANCES | - |
dc.subject.keywordPlus | INDUCED APOPTOSIS | - |
dc.subject.keywordPlus | GERMINAL CENTER | - |
dc.subject.keywordPlus | TNFAIP3 A20 | - |
dc.subject.keywordPlus | GENE | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | PROGNOSIS | - |
dc.subject.keywordPlus | TISSUE | - |
dc.subject.keywordPlus | CLASSIFICATION | - |
dc.subject.keywordAuthor | A20/TNFAIP3 | - |
dc.subject.keywordAuthor | fluorescence in situ hybridization | - |
dc.subject.keywordAuthor | diffuse large B-cell lymphoma | - |
dc.subject.keywordAuthor | prognosis | - |
dc.subject.keywordAuthor | deletion | - |
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