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MicroRNA-146a Downregulates NF kappa B Activity via Targeting TRAF6 and Functions as a Tumor Suppressor Having Strong Prognostic Implications in NK/T Cell Lymphoma
DC Field | Value | Language |
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dc.contributor.author | Paik, Jin Ho | - |
dc.contributor.author | Jang, Ji-Young | - |
dc.contributor.author | Jeon, Yoon Kyung | - |
dc.contributor.author | Kim, Wook Youn | - |
dc.contributor.author | Kim, Tae Min | - |
dc.contributor.author | Heo, Dae Seog | - |
dc.contributor.author | Kim, Chul-Woo | - |
dc.date.accessioned | 2023-05-08T00:51:50Z | - |
dc.date.available | 2023-05-08T00:51:50Z | - |
dc.date.created | 2021-06-09 | - |
dc.date.created | 2021-06-09 | - |
dc.date.issued | 2011-07 | - |
dc.identifier.citation | CLINICAL CANCER RESEARCH, Vol.17 No.14, pp.4761-4771 | - |
dc.identifier.issn | 1078-0432 | - |
dc.identifier.uri | https://hdl.handle.net/10371/192112 | - |
dc.description.abstract | Purpose: We investigated prognostic implications of microRNAs in extranodal NK/T cell lymphoma (NKTL). Experimental Design: We measured miRNA expression in NKTL tissues and cell lines, using real-time PCR, and analyzed its role in NKTL, using cell lines. Results: Multivariate analysis showed low miR-146a expression (P < 0.001; HR = 13.110), primary non-upper aerodigestive tract lesion (non-UAT; P = 0.008; HR = 5.376) and high International Prognostic Index (IPI; >= 3; P = 0.013; HR = 3.584) to be independent poor prognostic factors. miR-146a expression could subdivide UAT-NKTL into 2 prognostic groups, resulting in the following prognostic groups: (i) UAT(Low-146a), (ii) UAT(High-146a), and (iii) non-UAT. Compared with UAT(High-146a), UAT(Low-146a) showed distinctively poor prognosis (P < 0.001; HR = 15.620), similar to the non-UAT group. In vitro, miR-146a overexpression in NKTL cell lines, SNK6 and YT, inhibited nuclear factor kappa B (NF kappa B) activity, suppressed cell proliferation, induced apoptosis, and enhanced chemosensitivity. TNF receptor-associated factor 6, a target of miR-146a and a known NF kappa B activator, was downregulated by miR-146a in SNK6 and YT cells. Promoter methylation of miR-146a gene was observed in SNK6 and YT cells, as well as in NKTL tissues with low miR-146a expression, and miR-146a expression was induced by the conversion of methylation status with a demethylating agent in SNK6 and YT cells. Conclusions: These results suggest that miR-146a might function as a potent tumor suppressor in NKTL and be useful for patient assessment and therapeutic targeting. Clin Cancer Res; 17(14); 4761-71. (C)2011 AACR. | - |
dc.language | 영어 | - |
dc.publisher | AMER ASSOC CANCER RESEARCH | - |
dc.title | MicroRNA-146a Downregulates NF kappa B Activity via Targeting TRAF6 and Functions as a Tumor Suppressor Having Strong Prognostic Implications in NK/T Cell Lymphoma | - |
dc.type | Article | - |
dc.identifier.doi | 10.1158/1078-0432.CCR-11-0494 | - |
dc.citation.journaltitle | CLINICAL CANCER RESEARCH | - |
dc.identifier.wosid | 000292816900015 | - |
dc.identifier.scopusid | 2-s2.0-79960434259 | - |
dc.citation.endpage | 4771 | - |
dc.citation.number | 14 | - |
dc.citation.startpage | 4761 | - |
dc.citation.volume | 17 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Paik, Jin Ho | - |
dc.contributor.affiliatedAuthor | Heo, Dae Seog | - |
dc.contributor.affiliatedAuthor | Kim, Chul-Woo | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | INDUCED APOPTOSIS | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | TRANSCRIPTION | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | SURVIVAL | - |
dc.subject.keywordPlus | AKT | - |
dc.subject.keywordPlus | INVASIVENESS | - |
dc.subject.keywordPlus | DEREGULATION | - |
dc.subject.keywordPlus | MIR-146A | - |
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