Publications
Detailed Information
Longitudinal association between adiposity changes and lung function deterioration
Cited 0 time in
Web of Science
Cited 0 time in Scopus
- Authors
- Issue Date
- 2023-02-07
- Publisher
- BMC
- Citation
- Respiratory Research, 24(1):44
- Keywords
- Abdominal obesity ; Adiposity ; Body composition ; Spirometry ; Waist–hip ratio
- Abstract
- Background
The longitudinal relationship between adiposity and lung function is controversial. We aimed to investigate the long-term association between adiposity changes and lung function in a middle-aged general Asian population.
Methods
In total, 5011 participants (average age, 54years; 45% men) were enrolled from a community-based prospective cohort. During the follow-up period (median 8years), both spirometry and bio-electrical impedance analysis were performed biannually. Individual slopes of the fat mass index (FMI; fat mass divided by the square of height in meters) and waist-to-hip ratio (WHR) were calculated using linear regression analysis. Multivariate linear mixed regression analysis was used to determine the long-term association between adiposity changes and lung function.
Results
The FMI was inversely associated with forced vital capacity (FVC) (estimated: − 31.8mL in men, − 27.8mL in women) and forced expiratory volume in 1s (FEV1) (estimated: − 38.2mL in men, − 17.8mL in women) after adjusting for baseline age, height, residential area, smoking exposure (pack-years, men only), initial adiposity indices, and baseline lung function. The WHR was also inversely associated with FVC (estimated = − 1242.2mL) and FEV1 (estimated = − 849.8mL) in men. The WHR-increased group showed a more rapid decline in lung function than the WHR-decreased group in both the fat-gain and fat-loss groups.
Conclusion
Adiposity was associated with the long-term impairment of lung function. Central obesity was the main driver of lung function impairment in the middle-aged general Asian population, regardless of fat mass changes.
- ISSN
- 1465-993X
- Language
- English
- Files in This Item:
- Appears in Collections:
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.