Publications
Detailed Information
Effects of bioactive substance from turmeric on growth, skin mucosal immunity and antioxidant factors in common carp, Cyprinus carpio
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Giri, Sib Sankar | - |
dc.contributor.author | Sukumaran, V. | - |
dc.contributor.author | Park, Se Chang | - |
dc.date.accessioned | 2023-05-30T07:03:36Z | - |
dc.date.available | 2023-05-30T07:03:36Z | - |
dc.date.created | 2019-12-30 | - |
dc.date.created | 2019-12-30 | - |
dc.date.issued | 2019-09 | - |
dc.identifier.citation | Fish and Shellfish Immunology, Vol.92, pp.612-620 | - |
dc.identifier.issn | 1050-4648 | - |
dc.identifier.uri | https://hdl.handle.net/10371/192507 | - |
dc.description.abstract | Present study evaluated the effects of curcumin, the principal curcuminoid of turmeric, on Cyprinus carpio growth, skin mucosal immune parameters, immune-related gene expression, and susceptibility to pathogen challenge. Diets containing four various concentrations of curcumin (g Kg(-1)): 0 g [basal diet], 5 g [T5], 10 g [T10] and 15 g [T15] were fed to the carp (average weight: 16.37 g) for 8 weeks. Growth parameters were analysed at 4 and 8 weeks post-feeding. Skin mucosal immune responses and expression were examined in 8 weeks post-feeding. Growth performance was significantly higher in T10 and T15, with final weight gain of 102.26 +/- 2.31 g and specific growth rate of 3.24 +/- 0.37, respectively. The lowest feed conversion ratio (2.35 +/- 0.16) was recorded in T15 than in the control (P < 0.05). Among the skin mucosal immune parameters examined, lysozyme (36.8 +/- 4.03 U mL(-1)), total immunoglobulin (6.74 +/- 0.5 mg mL(-1)), protein level (18.7 +/- 1.62 mg mL(-1)), alkaline phosphatase (96.37 +/- 6.3 IU L-1), and protease activity (9.47 +/- 0.82%) were significantly higher in T15, while the peroxidase activity was higher in T10 (10.24 +/- 0.9 U mg(-1) protein). Further, lysozyme, superoxide dismutase (SOD) and catalase (CAT) activities were measured in serum and found to be higher in T10 or T15 than in the control (P < 0.05). However, malondialdehyde level decreased significantly in T10 and T15. Furthermore, antioxidant genes (SOD, CAT, nuclear factor erythroid 2-related factor 2) and anti-inflammatory cytokine Interleukin-10 were upregulated in the head kidney, intestine, and hepatopancreas of fish in T10 and T15. Conversely, expression of pro-inflammatory cytokines (IL-1 beta, tumour necrosis-factor-alpha), signalling molecule NF-kappa Bp65 were down-regulated in the tested tissues of T10 and T15. Expression of Toll-like receptor 22 (TLR22) was down regulated in head-kidney and intestine of T15. Fish from T15 exhibited significantly higher relative post-challenge survival (69.70%) against Aeromonas hydrophila challenge. Results of the present study suggest that dietary supplements of curcumin at 15g Kg(-1) lean significantly improve the growth performance, skin mucosal and serum antioxidant parameters, and strengthen the immunity of C. carpi. Therefore, curcumin represents a promising food additive for carps in aquaculture. | - |
dc.language | 영어 | - |
dc.publisher | Academic Press | - |
dc.title | Effects of bioactive substance from turmeric on growth, skin mucosal immunity and antioxidant factors in common carp, Cyprinus carpio | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.fsi.2019.06.053 | - |
dc.citation.journaltitle | Fish and Shellfish Immunology | - |
dc.identifier.wosid | 000483634300066 | - |
dc.identifier.scopusid | 2-s2.0-85068116906 | - |
dc.citation.endpage | 620 | - |
dc.citation.startpage | 612 | - |
dc.citation.volume | 92 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Park, Se Chang | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | PALM FRUIT EXTRACTS | - |
dc.subject.keywordPlus | NF-KAPPA-B | - |
dc.subject.keywordPlus | GINGER ZINGIBER-OFFICINALE | - |
dc.subject.keywordPlus | DISEASE RESISTANCE | - |
dc.subject.keywordPlus | RAINBOW-TROUT | - |
dc.subject.keywordPlus | DIETARY SUPPLEMENTATION | - |
dc.subject.keywordPlus | AEROMONAS-HYDROPHILA | - |
dc.subject.keywordPlus | INNATE IMMUNITY | - |
dc.subject.keywordPlus | PERFORMANCE | - |
dc.subject.keywordPlus | FISH | - |
dc.subject.keywordAuthor | Curcumin | - |
dc.subject.keywordAuthor | Carp | - |
dc.subject.keywordAuthor | Innate immunity | - |
dc.subject.keywordAuthor | Pathogen resistance | - |
dc.subject.keywordAuthor | Antioxidant | - |
dc.subject.keywordAuthor | Gene expression | - |
- Appears in Collections:
- Files in This Item:
- There are no files associated with this item.
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.