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Clinical significance of D-dimer levels during acute period in ischemic stroke
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Nam, Ki-Woong | - |
dc.contributor.author | Kwon, Hyung-Min | - |
dc.contributor.author | Lee, Yong-Seok | - |
dc.date.accessioned | 2023-06-28T01:27:49Z | - |
dc.date.available | 2023-06-28T10:28:30Z | - |
dc.date.issued | 2023-05-09 | - |
dc.identifier.citation | Thrombosis Journal,Vol.21:55 | ko_KR |
dc.identifier.issn | 1477-9560 | - |
dc.identifier.uri | https://hdl.handle.net/10371/192945 | - |
dc.description.abstract | Background
Initial D-dimer level is a well-known prognostic parameter in patients with acute ischemic stroke (AIS). However, there have been no studies on the clinical significance of follow-up D-dimer levels. In this study, we evaluated the association between initial and follow-up D-dimer levels and early neurological deterioration (END) in patients with AIS. Methods We included consecutive patients with AIS who had a positive initial D-dimer test (> 0.55mg/L) between March 2021 and November 2022. The follow-up D-dimer test was performed on the 7th day after hospitalization and on the day of discharge if discharged earlier. END was defined as an increase of ≥ 2 in the total NIHSS score, or ≥ 1 in the motor NIHSS score within the first 7 days of admission. As medical conditions closely associated with the initial and follow-up D-dimer levels in AIS patients, we also evaluated the history of cancer, active cancer, and venous thromboembolism (VTE) that occurred during hospitalization together. Results A total of 246 patients with AIS were evaluated (median age: 87 years, male: 56.5%). In multivariable logistic regression analysis, the initial D-dimer level was closely associated with END after adjusting for confounders (adjusted odds ratio [aOR]: 1.48, 95% CI: 1.06–2.05). The follow-up D-dimer level also showed a close correlation with END (aOR: 1.60, 95% CI: 1.16–2.20). Regarding the analysis of the association between D-dimer levels and underlying cancer or VTE, the initial D-dimer level showed a statistically significant positive relationship only with active cancer (P = 0.024). On the other hand, the follow-up D-dimer level was found to be statistically significantly associated with a history of cancer (P = 0.024), active cancer (P = 0.001), and VTE (P = 0.001). Conclusions Initial and follow-up D-dimer levels were associated with END in AIS patients. Particularly, the follow-up D-dimer level showed a clear correlation not only with END but also with the underlying cancer or the occurrence of VTE during the acute period. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | BMC | ko_KR |
dc.subject | D-dimer | - |
dc.subject | Ischemic strok | - |
dc.subject | Coagulopathy | - |
dc.subject | Early neurological deterioration | - |
dc.subject | Prognosis | - |
dc.title | Clinical significance of D-dimer levels during acute period in ischemic stroke | ko_KR |
dc.type | Article | ko_KR |
dc.identifier.doi | 10.1186/s12959-023-00496-1 | ko_KR |
dc.citation.journaltitle | Thrombosis Journal | ko_KR |
dc.language.rfc3066 | en | - |
dc.rights.holder | The Author(s) | - |
dc.date.updated | 2023-05-14T03:11:40Z | - |
dc.citation.number | 55 | ko_KR |
dc.citation.volume | 21 | ko_KR |
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