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Adhesive coacervate as a bioactive coating supplement for wound dressings : 상처 드레싱을 위한 생활성 코팅 보조제로서의 접착성 코아세르베이트
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- Authors
- Advisor
- 이강원
- Issue Date
- 2023
- Publisher
- 서울대학교 대학원
- Keywords
- Coacervate ; DOPA ; Drug Delivery System(DDS) ; sustained release profile
- Description
- 학위논문(석사) -- 서울대학교대학원 : 융합과학기술대학원 응용바이오공학과, 2023. 2. 이강원.
- Abstract
- Wound healing using growth factors is a clinically effective treatment method. However, it has a short biological half-life due to protease secreted into the wound area to break down the damaged extracellular matrix (ECM). The study shows a new coating supplement functionalizing adhesiveness using dopamine (DOPA) to the complex coacervate of fucoidan and poly-l-lysine (PLL), showing antioxidant properties that useful in wound healing. The dopamine-complex coacervate (D-Coa) was optimized to form maximum micro-droplets. The D-Coa, dopamine functionalized fucoidan, a marine-derived glycosaminoglycan, and poly-l-lysine (PLL) coacervates have shown promising protein delivery; sustained release profile, superior encapsulation ability, biocompatibility, and protection against harsh in-vivo environment, for tissue engineering applications as our previous fucoidan and poly-l-lysine (PLL) complex coacervate study was shown. Furthermore, the D-Coa was conducted superior adhesive forces and successfully coated onto collagen sponge homogeneously and rapidly. From in vivo performance tests using at skin defect models, our D-Coa coating patch were demonstrated successful wound regeneration. This game changer coating supplements can rescue biological half-life and reduce coating time, preventing limited application of scaffold such as commercially available collagen sponge.
- Language
- eng
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