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Comparison of initial and sequential salvage brain-directed treatment in patients with 1-4 vs. 5-10 brain metastases from breast cancer (KROG 16-12)
DC Field | Value | Language |
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dc.contributor.author | Kim, Jae Sik | - |
dc.contributor.author | Kim, Kyubo | - |
dc.contributor.author | Jung, Wonguen | - |
dc.contributor.author | Shin, Kyung Hwan | - |
dc.contributor.author | Im, Seock-Ah | - |
dc.contributor.author | Kim, Hee-Jun | - |
dc.contributor.author | Kim, Yong Bae | - |
dc.contributor.author | Chang, Jee Suk | - |
dc.contributor.author | Kim, Jee Hyun | - |
dc.contributor.author | Choi, Doo Ho | - |
dc.contributor.author | Park, Yeon Hee | - |
dc.contributor.author | Kim, Dae Yong | - |
dc.contributor.author | Kim, Tae Hyun | - |
dc.contributor.author | Choi, Byung Ock | - |
dc.contributor.author | Lee, Sea-Won | - |
dc.contributor.author | Kim, Suzy | - |
dc.contributor.author | Kwon, Jeanny | - |
dc.contributor.author | Kang, Ki Mun | - |
dc.contributor.author | Chung, Woong-Ki | - |
dc.contributor.author | Kim, Kyung Su | - |
dc.contributor.author | Yoon, Won Sup | - |
dc.contributor.author | Kim, Jin Hee | - |
dc.contributor.author | Cha, Jihye | - |
dc.contributor.author | Oh, Yoon Kyeong | - |
dc.contributor.author | Kim, In Ah | - |
dc.date.accessioned | 2023-07-04T05:40:21Z | - |
dc.date.available | 2023-07-04T05:40:21Z | - |
dc.date.created | 2023-06-19 | - |
dc.date.created | 2023-06-19 | - |
dc.date.created | 2023-06-19 | - |
dc.date.created | 2023-06-19 | - |
dc.date.created | 2023-06-19 | - |
dc.date.issued | 2023-07 | - |
dc.identifier.citation | Breast Cancer Research and Treatment, Vol.200 No.1, pp.37-45 | - |
dc.identifier.issn | 0167-6806 | - |
dc.identifier.uri | https://hdl.handle.net/10371/194670 | - |
dc.description.abstract | PurposeWe aimed to compare the initial and salvage brain-directed treatment and overall survival (OS) between patients with 1-4 brain metastases (BMs) and those with 5-10 from breast cancer (BC). We also organized a decision tree to select the initial whole-brain radiotherapy (WBRT) for these patients.MethodsBetween 2008 and 2014, 471 patients were diagnosed with 1-10 BMs. They were divided into two groups based on the number of BM: 1-4 BMs (n = 337) and 5-10 BMs (n = 134). Median follow-up duration was 14.0 months.ResultsStereotactic radiosurgery (SRS)/fractionated stereotactic radiotherapy (FSRT) was the most common treatment modality (n = 120, 36%) in the 1-4 BMs group. In contrast, 80% (n = 107) of patients with 5-10 BMs were treated with WBRT. The median OS of the entire cohort, 1-4 BMs, and 5-10 BMs was 18.0, 20.9, and 13.9 months, respectively. In the multivariate analysis, the number of BM and WBRT were not associated with OS, whereas triple-negative BC and extracranial metastasis decreased OS. Physicians determined the initial WBRT based on four variables in the following order: number and location of BM, primary tumor control, and performance status. Salvage brain-directed treatment (n = 184), mainly SRS/FSRT (n = 109, 59%), prolonged OS by a median of 14.3 months.ConclusionThe initial brain-directed treatment differed notably according to the number of BM, which was chosen based on four clinical factors. In patients with <= 10 BMs, the number of BM and WBRT did not affect OS. The major salvage brain-directed treatment modality was SRS/FSRT and increased OS. | - |
dc.language | 영어 | - |
dc.publisher | Kluwer Academic Publishers | - |
dc.title | Comparison of initial and sequential salvage brain-directed treatment in patients with 1-4 vs. 5-10 brain metastases from breast cancer (KROG 16-12) | - |
dc.type | Article | - |
dc.identifier.doi | 10.1007/s10549-023-06936-w | - |
dc.citation.journaltitle | Breast Cancer Research and Treatment | - |
dc.identifier.wosid | 000980807400001 | - |
dc.identifier.scopusid | 2-s2.0-85158133774 | - |
dc.citation.endpage | 45 | - |
dc.citation.number | 1 | - |
dc.citation.startpage | 37 | - |
dc.citation.volume | 200 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Im, Seock-Ah | - |
dc.contributor.affiliatedAuthor | Kim, In Ah | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordAuthor | Breast cancer | - |
dc.subject.keywordAuthor | Brain metastasis | - |
dc.subject.keywordAuthor | Overall survival | - |
dc.subject.keywordAuthor | Salvage treatment | - |
dc.subject.keywordAuthor | Whole-brain radiotherapy | - |
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