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Dietary Syzygium cumini leaf extract influences growth performance, immunological responses and gene expression in pathogen-challenged Cyprinus carpio
DC Field | Value | Language |
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dc.contributor.author | Giri, Sib Sankar | - |
dc.contributor.author | Kim, Sang Guen | - |
dc.contributor.author | Jung, Won Joon | - |
dc.contributor.author | Lee, Sung Bin | - |
dc.contributor.author | Lee, Young Min | - |
dc.contributor.author | Jo, Su Jin | - |
dc.contributor.author | Hwang, Mae Hyun | - |
dc.contributor.author | Park, Jae Hong | - |
dc.contributor.author | Kim, Ji Hyung | - |
dc.contributor.author | Saha, Subrata | - |
dc.contributor.author | Sukumaran, Venkatachalam | - |
dc.contributor.author | Park, Se Chang | - |
dc.date.accessioned | 2023-07-07T07:56:49Z | - |
dc.date.available | 2023-07-07T07:56:49Z | - |
dc.date.created | 2023-07-07 | - |
dc.date.created | 2023-07-07 | - |
dc.date.created | 2023-07-07 | - |
dc.date.created | 2023-07-07 | - |
dc.date.created | 2023-07-07 | - |
dc.date.issued | 2023-07 | - |
dc.identifier.citation | Fish and Shellfish Immunology, Vol.138, p. 108830 | - |
dc.identifier.issn | 1050-4648 | - |
dc.identifier.uri | https://hdl.handle.net/10371/194721 | - |
dc.description.abstract | This study evaluated the effects of jamun leaf extract (JLE) as a feed supplement on growth performance, haemato-immunological, oxidative stress-related parameters, and cytokine gene expression in Cyprinus carpio challenged with Aeromonas hydrophila.. Diets containing four different JLE concentrations, that is, 0 (basal diet), 5 (JLE5), 10 (JLE10), and 15 g kg-1 (JLE15), were fed to carp (6.17 & PLUSMN; 0.43 g) for eight weeks. Growth per-formance was significantly higher in JLE10. Haemato-immunological and antioxidant parameters were deter-mined in fish at 48 h post-challenge with A. hydrohila. The cumulative survival was highest in JLE10 (69.69%) 14 days post-challenge. Serum protein (2.18 & PLUSMN; 0.06 g dL-1), lysozyme (32.38 & PLUSMN; 1.2 U mL-1), alternative com-plement pathway (70.43 & PLUSMN; 1.61 U mL-1), phagocytic activity (21.18 & PLUSMN; 0.48%), respiratory burst activity (0.289 & PLUSMN; 0.09 OD630nm), and immunoglobulin levels (6.67 & PLUSMN; 0.36 U mg mL-1) were significantly higher in JLE10 than in the control. Serum alanine aminotransferase (44.06 & PLUSMN; 1.62 Unit mL-1), aspartate aminotransferase (31.58 & PLUSMN; 1.82 Unit mL-1), and malondialdehyde (2.57 & PLUSMN; 0.26 nmol mL-1) levels were lower in JLE10 than in the control (p < 0.05), whereas myeloperoxidase activity was significantly higher in JLE5 and JLE10 than in the control. Superoxide dismutase levels in the serum were higher (p < 0.05) in JLE5 and JLE10 than in the other groups. Gene expression analysis revealed that the mRNA expression of pro-inflammatory cytokines TNF-& alpha; and IL-1 & beta; was upregulated (p < 0.05) in the liver, head-kidney, and intestine of challenged carp in JLE10. The signalling molecule NF-& kappa;B p65 was upregulated in lymphoid organs in JLE10 but not in the liver. The anti-inflammatory cytokine IL-10 was significantly downregulated in challenged carp in JLE10 compared with that in the con-trol. Quadratic regression analysis showed that optimal dietary JLE was estimated to be 9.03-10.15 g kg-1 to maximize the growth performance. Results of the present study revealed that dietary JLE at 10 g kg-1 can significantly improve the immunity and disease resistance of C. carpio. Thus, JLE is a promising food additive for carp aquaculture. | - |
dc.language | 영어 | - |
dc.publisher | Academic Press | - |
dc.title | Dietary Syzygium cumini leaf extract influences growth performance, immunological responses and gene expression in pathogen-challenged Cyprinus carpio | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.fsi.2023.108830 | - |
dc.citation.journaltitle | Fish and Shellfish Immunology | - |
dc.identifier.wosid | 001012897900001 | - |
dc.identifier.scopusid | 2-s2.0-85161075024 | - |
dc.citation.startpage | 108830 | - |
dc.citation.volume | 138 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Park, Se Chang | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | IMMUNE-RELATED GENES | - |
dc.subject.keywordPlus | DISEASE RESISTANCE | - |
dc.subject.keywordPlus | LABEO-ROHITA | - |
dc.subject.keywordPlus | COMMON CARP | - |
dc.subject.keywordPlus | INFLAMMATORY CYTOKINES | - |
dc.subject.keywordPlus | AEROMONAS-HYDROPHILA | - |
dc.subject.keywordPlus | NONSPECIFIC IMMUNITY | - |
dc.subject.keywordPlus | INNATE IMMUNITY | - |
dc.subject.keywordPlus | GRASS CARP | - |
dc.subject.keywordPlus | FISH | - |
dc.subject.keywordAuthor | Jamun leaf extract | - |
dc.subject.keywordAuthor | Carp | - |
dc.subject.keywordAuthor | Antioxidant | - |
dc.subject.keywordAuthor | Immunity | - |
dc.subject.keywordAuthor | Gene expression | - |
dc.subject.keywordAuthor | Aeromonas hydrophila | - |
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