Publications
Detailed Information
Transient lymphopenia and interstitial pneumonia with endotheliitis in SARS-CoV-2-infected macaques
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Koo, Bon-Sang | - |
dc.contributor.author | Oh, Hanseul | - |
dc.contributor.author | Kim, Green | - |
dc.contributor.author | Hwang, Eun-Ha | - |
dc.contributor.author | Jung, Hoyin | - |
dc.contributor.author | Lee, Youngjeon | - |
dc.contributor.author | Kang, Philyong | - |
dc.contributor.author | Park, Jae-Hak | - |
dc.contributor.author | Ryu, Choong-Min | - |
dc.contributor.author | Hong, Jung Joo | - |
dc.date.accessioned | 2023-07-07T07:57:46Z | - |
dc.date.available | 2023-07-07T07:57:46Z | - |
dc.date.created | 2021-02-05 | - |
dc.date.created | 2021-02-05 | - |
dc.date.created | 2021-02-05 | - |
dc.date.issued | 2020-11 | - |
dc.identifier.citation | Journal of Infectious Diseases, Vol.222 No.10, pp.1596-1600 | - |
dc.identifier.issn | 0022-1899 | - |
dc.identifier.uri | https://hdl.handle.net/10371/194741 | - |
dc.description.abstract | Using a reliable primate model is critical for developing therapeutic advances to treat humans infected with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Here, we exposed macaques to high titers of SARS-CoV-2 via combined transmission routes. We observed acute interstitial pneumonia with endotheliitis in the lungs of all infected macaques. All macaques had a significant loss of total lymphocytes during infection, which were restored over time. These data show that SARS-CoV-2 causes a coronavirus disease 2019 (COVID-19)-like disease in macaques. This new model could investigate the interaction between SARS-CoV-2 and the immune system to test therapeutic strategies. | - |
dc.language | 영어 | - |
dc.publisher | University of Chicago Press | - |
dc.title | Transient lymphopenia and interstitial pneumonia with endotheliitis in SARS-CoV-2-infected macaques | - |
dc.type | Article | - |
dc.identifier.doi | 10.1093/infdis/jiaa486 | - |
dc.citation.journaltitle | Journal of Infectious Diseases | - |
dc.identifier.wosid | 000605980300006 | - |
dc.identifier.scopusid | 2-s2.0-85092945746 | - |
dc.citation.endpage | 1600 | - |
dc.citation.number | 10 | - |
dc.citation.startpage | 1596 | - |
dc.citation.volume | 222 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Park, Jae-Hak | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | SARS | - |
dc.subject.keywordAuthor | macaques | - |
dc.subject.keywordAuthor | lymphopenia | - |
dc.subject.keywordAuthor | pneumonia | - |
dc.subject.keywordAuthor | SARS-CoV-2 | - |
- Appears in Collections:
- Files in This Item:
- There are no files associated with this item.
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.