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Receptor Interacting Protein 2 (RIP2) Is Dispensable for OVA-Induced Airway Inflammation in Mice
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Tae-Hyoun | - |
dc.contributor.author | Park, Yeong-Min | - |
dc.contributor.author | Ryu, Seung-Wook | - |
dc.contributor.author | Kim, Dong-Jae | - |
dc.contributor.author | Park, Jae-Hak | - |
dc.contributor.author | Park, Jong-Hwan | - |
dc.date.accessioned | 2023-07-07T08:00:04Z | - |
dc.date.available | 2023-07-07T08:00:04Z | - |
dc.date.created | 2020-07-23 | - |
dc.date.created | 2020-07-23 | - |
dc.date.issued | 2014-03 | - |
dc.identifier.citation | Allergy, Asthma & Immunology Research, Vol.6 No.2, pp.163-168 | - |
dc.identifier.issn | 2092-7355 | - |
dc.identifier.uri | https://hdl.handle.net/10371/194788 | - |
dc.description.abstract | Purpose: Asthma is a pulmonary chronic inflammatory disease characterized by airway obstruction and hyperresponsiveness. Pattern recognition receptors are known to play a key role in the development of allergic diseases as well as host defenses against microbial infection. Receptor interacting protein 2 (RIP2), a serine/threonine kinase, is an adaptor molecule of NOD1 and NOD2, and genetic variation in this receptor is known to be associated with-the severity of allergic asthma in children. In this study, we examined the role of RIP2 in the development of allergic airway inflammation in a mouse model. Methods: Airway inflammation was induced in mice through intranasal administration of ovalbumin (OVA) after 2 intraperitoneal immunizations with OVA. Lung inflammation and mucus hypersecretion were examined histologically and total cell infiltration in bronchoalveolar (BAL) fluids was determined. Levels of the Th2-related cytokines, IL-5 and IL-13, in lung extracts were measured by ELISA. Serum antigen-specific IgE and IgG1 levels were also assessed. Results: OVA-induced lung inflammation and mucus hypersecretion were not different between WT and RIP2-deficient mice. The IL-5 and IL-13 levels in the bronchoalveolar (BAL) fluids were also not impaired in RIP2-deficient mice compared to WT mice. Moreover, RIP2 deficiency did not affect serum OVA-specific IgG1 and IgE levels. Conclusions: Our results suggest that RIP2 is not associated with the development of allergic airway inflammation. | - |
dc.language | 영어 | - |
dc.publisher | 대한천식알레르기학회 | - |
dc.title | Receptor Interacting Protein 2 (RIP2) Is Dispensable for OVA-Induced Airway Inflammation in Mice | - |
dc.type | Article | - |
dc.identifier.doi | 10.4168/aair.2014.6.2.163 | - |
dc.citation.journaltitle | Allergy, Asthma & Immunology Research | - |
dc.identifier.wosid | 000333066600011 | - |
dc.identifier.scopusid | 2-s2.0-84894414817 | - |
dc.citation.endpage | 168 | - |
dc.citation.number | 2 | - |
dc.citation.startpage | 163 | - |
dc.citation.volume | 6 | - |
dc.identifier.kciid | ART001850789 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Park, Jae-Hak | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | TOLL-LIKE RECEPTORS | - |
dc.subject.keywordPlus | IMMUNOGLOBULIN-E | - |
dc.subject.keywordPlus | IMMUNE-RESPONSE | - |
dc.subject.keywordPlus | ASTHMA | - |
dc.subject.keywordPlus | INNATE | - |
dc.subject.keywordPlus | RECOGNITION | - |
dc.subject.keywordPlus | INFECTION | - |
dc.subject.keywordPlus | NOD1 | - |
dc.subject.keywordPlus | PATHOGENESIS | - |
dc.subject.keywordPlus | ASSOCIATION | - |
dc.subject.keywordAuthor | RIP2 | - |
dc.subject.keywordAuthor | ovalbumin | - |
dc.subject.keywordAuthor | airway inflammation | - |
dc.subject.keywordAuthor | Th2 | - |
dc.subject.keywordAuthor | IgE | - |
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