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Antiobesity effect of trans-10,cis-12-conjugated linoleic acid-producing Lactobacillus plantarum PL62 on diet-induced obese mice
Cited 140 time in
Web of Science
Cited 158 time in Scopus
- Authors
- Issue Date
- 2007-01
- Publisher
- Blackwell Publishing Inc.
- Citation
- Journal of Applied Microbiology, Vol.103 No.4, pp.1140-1146
- Abstract
- Aims: To observe the antiobesity activity of trans-10,cis-12-conjugated linoleic acid (CLA)-producing lactobacillus in mice. Methods and Results: Lactobacillus plantarum PL62, which can grow in the presence of linoleic acid, was selected and studied. The culture supernatant of Lact. plantarum PL62 contained trans-10,cis-12-conjugated linoleic acid (6.4 mu g ml(-1)), and the crude enzyme prepared from washed cells produced trans-10,cis-12 CLA (1395 mu g mg(-1) protein). Lact. plantarum PL62 reduced the weights of epididymal, inguinal, mesenteric, and perirenal white adipose tissues and significantly reduced the blood levels of total glucose and body weights of mice (P < 0.01). Conclusions: trans-10,cis-12-CLA-producing Lact. plantarum PL62 can exert the same antiobesity activity as trans-10,cis-12-CLA in mice. Significance and impact of the study: trans-10,cis-12-CLA-producing Lactobacillus can be a replacement for CLA for obesity treatment via the continuous production of trans-10,cis-12-CLA. The results provide a novel opportunity to develop foods with antiobesity activity.
- ISSN
- 1364-5072
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