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Caffeoyl-Pro-His amide relieve DNCB-Induced Atopic Dermatitis-Like phenotypes in BALB/c mice
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jang, Sunhyae | - |
dc.contributor.author | Ohn, Jungyoon | - |
dc.contributor.author | Kim, Ji Won | - |
dc.contributor.author | Kang, So Min | - |
dc.contributor.author | Jeon, Dasom | - |
dc.contributor.author | Heo, Chan Yeong | - |
dc.contributor.author | Lee, Yoon-Sik | - |
dc.contributor.author | Kwon, Ohsang | - |
dc.contributor.author | Kim, Kyu Han | - |
dc.date.accessioned | 2023-07-10T07:07:00Z | - |
dc.date.available | 2023-07-10T07:07:00Z | - |
dc.date.created | 2020-09-09 | - |
dc.date.issued | 2020-12 | - |
dc.identifier.citation | Scientific Reports, Vol.10 No.1, p. 8417 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | https://hdl.handle.net/10371/194971 | - |
dc.description.abstract | The main factors involved in the pathogenesis of atopic dermatitis (AD) are skin barrier abnormality, allergy/immunology, and pruritus. Considering how oxidative stress influences these factors, antioxidant agents may be effective candidates in the treatment of AD. To evaluate the effect of Caffeoyl-Pro-His amide (CA-PH), an antioxidant agent, on 2,4-dinitrochlorobenzene (DNCB)-induced AD-like phenotypes in BALB/c mice. Topical sensitization and challenge by DNCB were performed on the dorsal skin of BALB/c mice to induce AD-like cutaneous lesions, phenotypes, and immunologic response. CA-PH was applied topically for 2 weeks to assess its effects on DNCB-induced AD-like phenotypes. As a result, CA-PH relieved DNCB-induced AD-like phenotypes quantified by dermatitis severity score, scratching duration, and trans-epidermal water loss. Histopathological analysis showed that CA-PH decreased epidermal thickening, the number of mast cells, and eosinophil infiltration in dermis. Immunohistochemical staining revealed that CA-PH recovered skin barrier-related proteins: filaggrin, involucrin, and loricrin. As for the immunologic aspects, CA-PH treatment lowered mRNA or protein levels of interleukin (IL)-4, IL-6, IL-17a, IL-1b, IL-31, and IL-33 levels and thymic stromal lymphopoietin (TSLP) levels in cutaneous tissue, reducing the DNCB-induced serum IgE level elevation. In conclusion, topical CA-PH may be a therapeutic option for the treatment of AD. | - |
dc.language | 영어 | - |
dc.publisher | Nature Publishing Group | - |
dc.title | Caffeoyl-Pro-His amide relieve DNCB-Induced Atopic Dermatitis-Like phenotypes in BALB/c mice | - |
dc.type | Article | - |
dc.identifier.doi | 10.1038/s41598-020-65502-2 | - |
dc.citation.journaltitle | Scientific Reports | - |
dc.identifier.wosid | 000560441200029 | - |
dc.identifier.scopusid | 2-s2.0-85085157782 | - |
dc.citation.number | 1 | - |
dc.citation.startpage | 8417 | - |
dc.citation.volume | 10 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Heo, Chan Yeong | - |
dc.contributor.affiliatedAuthor | Lee, Yoon-Sik | - |
dc.contributor.affiliatedAuthor | Kwon, Ohsang | - |
dc.contributor.affiliatedAuthor | Kim, Kyu Han | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | SKIN BARRIER FUNCTION | - |
dc.subject.keywordPlus | THYMIC STROMAL LYMPHOPOIETIN | - |
dc.subject.keywordPlus | TRANSEPIDERMAL WATER-LOSS | - |
dc.subject.keywordPlus | ANTIOXIDATIVE ACTIVITIES | - |
dc.subject.keywordPlus | ACUTE EXACERBATION | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | IMMUNE-RESPONSES | - |
dc.subject.keywordPlus | ACID | - |
dc.subject.keywordPlus | CHILDREN | - |
dc.subject.keywordPlus | CELLS | - |
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