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Genetic and environmental relationships between Framingham Risk Score and adiposity measures in Koreans: The Healthy Twin Study
DC Field | Value | Language |
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dc.contributor.author | Song, Y. | - |
dc.contributor.author | Lee, K. | - |
dc.contributor.author | Sung, J. | - |
dc.contributor.author | Lee, D. | - |
dc.contributor.author | Lee, M. K. | - |
dc.contributor.author | Lee, J. Y. | - |
dc.date.accessioned | 2023-07-14T04:31:17Z | - |
dc.date.available | 2023-07-14T04:31:17Z | - |
dc.date.created | 2020-11-06 | - |
dc.date.issued | 2012-06 | - |
dc.identifier.citation | Nutrition, Metabolism and Cardiovascular Diseases, Vol.22 No.6, pp.503-509 | - |
dc.identifier.issn | 0939-4753 | - |
dc.identifier.uri | https://hdl.handle.net/10371/195174 | - |
dc.description.abstract | Background and aims: We examined heritability and bivariate analyses for the Framingham Risk Score (FRS) and adiposity measures among Koreans. Methods and results: We analysed the data from 2496 participants (962 men, 1534 women, age 30-74 years), including 1320 non-twin family members, 468 monozygotic (MZ) and 120 dizygotic (DZ) twin pairs, collected from the Healthy Twin study of Korea. Adiposity measurements comprised BMI, waist circumference (WC), waist-to-hip ratio and waist-to-height ratio (WHTR). Analyses were conducted using the Sequential Oligogenic Linkage Analysis Routines (SOLAR) package software. The co-twin control analyses shows that estimates of within-pair regression coefficients in the relationship between adiposity traits and FRS were attenuated for MZ twin pairs, relative to DZ twin pairs (0.11-0.26 vs. 0.60-0.71). The heritability estimate for FRS was 0.37, and the estimates for adiposity traits ranged from 0.45 to 0.63 (P < 0.001). Bivariate analysis revealed genetic correlations between FRS, and all of the adiposity traits ranged from 0.16 (for WHTR, P > 0.05) to 0.46 (for WC, P < 0.001). The common environmental correlations between FRS and each of the adiposity traits ranged from 0.43 to 0.66 (P < 0.001). Conclusions: FRS and each of the obesity traits shared common genetic and environmental relationships. These findings support a pleiotropic action between genes associated with adiposity traits and FRS and a need of further investigations for identifying specific common environmental factors. (C) 2010 Elsevier B.V. All rights reserved. | - |
dc.language | 영어 | - |
dc.publisher | Medikal Press s.r.l. | - |
dc.title | Genetic and environmental relationships between Framingham Risk Score and adiposity measures in Koreans: The Healthy Twin Study | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.numecd.2010.09.004 | - |
dc.citation.journaltitle | Nutrition, Metabolism and Cardiovascular Diseases | - |
dc.identifier.wosid | 000304245600006 | - |
dc.identifier.scopusid | 2-s2.0-84861193710 | - |
dc.citation.endpage | 509 | - |
dc.citation.number | 6 | - |
dc.citation.startpage | 503 | - |
dc.citation.volume | 22 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Sung, J. | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | MYOCARDIAL-INFARCTION | - |
dc.subject.keywordPlus | AMERICAN-INDIANS | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | HEART | - |
dc.subject.keywordPlus | FEATURES | - |
dc.subject.keywordPlus | FAMILY | - |
dc.subject.keywordAuthor | Heritability | - |
dc.subject.keywordAuthor | Framingham Risk Score | - |
dc.subject.keywordAuthor | Bivariate analysis | - |
dc.subject.keywordAuthor | Adiposity | - |
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