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Lung cancer probability and clinical outcomes of baseline and new subsolid nodules detected on low-dose CT screening
DC Field | Value | Language |
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dc.contributor.author | Kim, Yeon Wook | - |
dc.contributor.author | Kwon, Byoung Soo | - |
dc.contributor.author | Lim, Sung Yoon | - |
dc.contributor.author | Lee, Yeon Joo | - |
dc.contributor.author | Park, Jong Sun | - |
dc.contributor.author | Cho, Young-Jae | - |
dc.contributor.author | Yoon, Ho Il | - |
dc.contributor.author | Lee, Kyung Won | - |
dc.contributor.author | Lee, Jae Ho | - |
dc.contributor.author | Chung, Jin-Haeng | - |
dc.contributor.author | Ji, Eunjeong | - |
dc.contributor.author | Lee, Choon-Taek | - |
dc.date.accessioned | 2023-07-21T07:00:08Z | - |
dc.date.available | 2023-07-21T07:00:08Z | - |
dc.date.created | 2021-10-08 | - |
dc.date.created | 2021-10-08 | - |
dc.date.issued | 2021-10 | - |
dc.identifier.citation | Thorax, Vol.76 No.10, pp.980-988 | - |
dc.identifier.issn | 0040-6376 | - |
dc.identifier.uri | https://hdl.handle.net/10371/195206 | - |
dc.description.abstract | Background Limited data are available regarding the management of subsolid nodules detected on lung cancer screening with low-dose CT (LDCT). We aimed to determine the characteristics of screen-detected subsolid nodules, and to evaluate the probability of lung cancer and the clinical course of subsolid nodules detected at baseline and during follow-up screening. Methods We evaluated 50 132 asymptomatic adults (22 631 never-smokers and 27 501 ever-smokers) who underwent LDCT screening for lung cancer between May 2003 and June 2019 at a tertiary centre in South Korea. The incidence, characteristics and clinical outcomes of the baseline and new screen-detected subsolid nodules were determined. Results A total of 6725 subsolid nodules (5116 pure ground glass opacity nodules and 1609 part-solid nodules) were detected in 4545 participants (1484 new subsolid nodules detected in 937 (1.9%) participants; the overall incidence of subsolid nodules: 10.7% in never-smokers and 7.7% in ever-smokers, p<0.001). Among 4918 subsolid nodules that underwent follow-up with CT scans (the mean number of CT scans, including the baseline LDCT scan: 4.6), 2116 nodules (30.0% of baseline subsolid nodules and 78.9% of new subsolid nodules) resolved spontaneously. Among 293 biopsied subsolid nodules, 227 (77.5%) nodules were diagnosed as lung cancer, of which 226 (99.6%) were adenocarcinomas. No significant difference was observed in pathological invasiveness or the initial stage between the baseline and new cancerous subsolid nodules. Multivariable analyses revealed that new detection at follow-up screening was significantly associated with a lower probability of lung cancer (OR 0.26, 95% CI 0.14 to 0.49) and overall growth (OR 0.39, 95% CI 0.26 to 0.59), but with a higher probability of resolution (OR 6.30, 95% CI 5.09 to 7.81). Conclusions LDCT screening led to a considerably high rate of subsolid nodule detection, particularly in never-smokers. Compared with the baseline subsolid nodules, the new subsolid nodules were associated with a lower probability of lung cancer and higher probability of spontaneous resolution, indicating their more inflammatory nature. Less aggressive follow-up may be allowed for new subsolid nodules, particularly in screening programmes for Asian populations. | - |
dc.language | 영어 | - |
dc.publisher | BMJ Publishing Group | - |
dc.title | Lung cancer probability and clinical outcomes of baseline and new subsolid nodules detected on low-dose CT screening | - |
dc.type | Article | - |
dc.identifier.doi | 10.1136/thoraxjnl-2020-215107 | - |
dc.citation.journaltitle | Thorax | - |
dc.identifier.wosid | 000700182400007 | - |
dc.identifier.scopusid | 2-s2.0-85104398281 | - |
dc.citation.endpage | 988 | - |
dc.citation.number | 10 | - |
dc.citation.startpage | 980 | - |
dc.citation.volume | 76 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Park, Jong Sun | - |
dc.contributor.affiliatedAuthor | Yoon, Ho Il | - |
dc.contributor.affiliatedAuthor | Lee, Kyung Won | - |
dc.contributor.affiliatedAuthor | Lee, Jae Ho | - |
dc.contributor.affiliatedAuthor | Chung, Jin-Haeng | - |
dc.contributor.affiliatedAuthor | Lee, Choon-Taek | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | GROUND-GLASS OPACITY | - |
dc.subject.keywordPlus | STAGING PROJECT PROPOSALS | - |
dc.subject.keywordPlus | FORTHCOMING 8TH EDITION | - |
dc.subject.keywordPlus | PART-SOLID NODULES | - |
dc.subject.keywordPlus | NEVER-SMOKERS | - |
dc.subject.keywordPlus | TNM CLASSIFICATION | - |
dc.subject.keywordPlus | RISK-FACTORS | - |
dc.subject.keywordPlus | LONG | - |
dc.subject.keywordPlus | MANAGEMENT | - |
dc.subject.keywordPlus | LESIONS | - |
dc.subject.keywordAuthor | lung cancer | - |
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