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Alterations in intracellular Ca2+ levels in human endometrial stromal cells after decidualization
DC Field | Value | Language |
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dc.contributor.author | Sohn, Jie Ohn | - |
dc.contributor.author | Seong, Seung Yong | - |
dc.contributor.author | Kim, Hyun Jin | - |
dc.contributor.author | Jo, Yoon Mi | - |
dc.contributor.author | Lee, Kyoung Hoon | - |
dc.contributor.author | Chung, Mi Kyung | - |
dc.contributor.author | Song, Hyun Jin | - |
dc.contributor.author | Park, Kyoung Sun | - |
dc.contributor.author | Lim, Jeong Mook | - |
dc.date.accessioned | 2023-07-21T07:02:41Z | - |
dc.date.available | 2023-07-21T07:02:41Z | - |
dc.date.created | 2019-11-28 | - |
dc.date.issued | 2019-07 | - |
dc.identifier.citation | Biochemical and Biophysical Research Communications, Vol.515 No.2, pp.318-324 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.uri | https://hdl.handle.net/10371/195255 | - |
dc.description.abstract | Calcium (Ca2+) is an important element for many physiological functions of the uterus, including embryo implantation. Here, we investigated the possible involvement of altered intracellular Ca2+ levels in decidualization in human endometrial stromal cells (hEMSCs). hEMSCs showed high levels of mesenchymal stem cell marker expression (CD73, CD90, and CD105) and did not express markers of hematopoietic progenitor cells (CD31, CD34, CD45, and HLA-DR). Decidualization is a process of ovarian steroid-induced endometrial stromal cell proliferation and differentiation. Several types of ion channels, which are regulated by the ovarian hormones progesterone and estradiol, as well as growth factors, are important for endometrial receptivity and embryo implantation. The combined application of progesterone (1 mu M medroxyprogesterone acetate) and cyclic AMP (0.5 mM) for 6 days not only elevated inositol 1,4,5-triphosphate receptor (IP3R)-mediated Ca2+ release and IP3R expression, it also promoted ORAL and STIM expression as well as cyclopiazonic acid-induced Ca2+ release. Finally, intracellular Ca2+ levels and ion channel gene expression influenced hEMSC proliferation. These results suggest that cytosolic Ca2+ dynamics, mediated by specific ion channels, serve as an important step in the decidualization of hEMSCs. (C) 2019 The Authors. Published by Elsevier Inc. | - |
dc.language | 영어 | - |
dc.publisher | Academic Press | - |
dc.title | Alterations in intracellular Ca2+ levels in human endometrial stromal cells after decidualization | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.bbrc.2019.05.153 | - |
dc.citation.journaltitle | Biochemical and Biophysical Research Communications | - |
dc.identifier.wosid | 000472586600010 | - |
dc.identifier.scopusid | 2-s2.0-85066268330 | - |
dc.citation.endpage | 324 | - |
dc.citation.number | 2 | - |
dc.citation.startpage | 318 | - |
dc.citation.volume | 515 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Seong, Seung Yong | - |
dc.contributor.affiliatedAuthor | Lim, Jeong Mook | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | CALCIUM OSCILLATIONS | - |
dc.subject.keywordPlus | CELLULAR MECHANISMS | - |
dc.subject.keywordPlus | DIFFERENTIATION | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | CHANNELS | - |
dc.subject.keywordPlus | HOMEOSTASIS | - |
dc.subject.keywordPlus | ENTRY | - |
dc.subject.keywordPlus | MICE | - |
dc.subject.keywordAuthor | Endometrial stromal cells | - |
dc.subject.keywordAuthor | Decidualization | - |
dc.subject.keywordAuthor | Ion channels | - |
dc.subject.keywordAuthor | Cytosolic Ca2+ regulation | - |
dc.subject.keywordAuthor | Proliferation | - |
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