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Comparison of Myelin Water Fraction Values in White Matter Lesions between Multiple Sclerosis and Neuromyelitis Optica Spectrum Disorder
Cited 19 time in
Web of Science
Cited 20 time in Scopus
- Authors
- Issue Date
- 2016-10
- Publisher
- SAGE Publications
- Citation
- Multiple Sclerosis, Vol.22 No.3, pp.1616-1620
- Abstract
- Multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD) are inflammatory autoimmune diseases of the central nervous system. We hypothesized that the degree of demyelination within lesions in MS and NMOSD would differ as the pathophysiology of the two diseases do. We used myelin water imaging to compare the myelin water fraction (MWF) in 106 periventricular white matter (PVWM) lesions in 27 MS patients and 51 PVWM lesions in 20 NMOSD patients. The MWF was significantly reduced in the MS compared with the NMOSD lesions, suggesting that myelin loss was more severe in MS than in NMOSD.
- ISSN
- 1352-4585
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