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TROPION-Breast01: Datopotamab deruxtecan vs chemotherapy in pre-treated inoperable or metastatic HR+/HER2-breast cancer
DC Field | Value | Language |
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dc.contributor.author | Bardia, Aditya | - |
dc.contributor.author | Jhaveri, Komal | - |
dc.contributor.author | Kalinsky, Kevin | - |
dc.contributor.author | Pernas, Sonia | - |
dc.contributor.author | Tsurutani, Junji | - |
dc.contributor.author | Xu, Binghe | - |
dc.contributor.author | Hamilton, Erika | - |
dc.contributor.author | Im, Seock-Ah | - |
dc.contributor.author | Nowecki, Zbigniew | - |
dc.contributor.author | Sohn, Joohyuk | - |
dc.contributor.author | De Laurentiis, Michelino | - |
dc.contributor.author | Martinez Janez, Noelia | - |
dc.contributor.author | Adamo, Barbara | - |
dc.contributor.author | Lee, Keun Seok | - |
dc.contributor.author | Jung, Kyung Hae | - |
dc.contributor.author | Rubovszky, Gabor | - |
dc.contributor.author | Tseng, Ling-Ming | - |
dc.contributor.author | Lu, Yen-Shen | - |
dc.contributor.author | Yuan, Yuan | - |
dc.contributor.author | Maxwell, Micah J. | - |
dc.contributor.author | Haddad, Vincent | - |
dc.contributor.author | Khan, Sabrina S. | - |
dc.contributor.author | Rugo, Hope S. | - |
dc.contributor.author | Pistilli, Barbara | - |
dc.date.accessioned | 2023-10-30T01:43:58Z | - |
dc.date.available | 2023-10-30T01:43:58Z | - |
dc.date.created | 2023-09-06 | - |
dc.date.created | 2023-09-06 | - |
dc.date.created | 2023-09-06 | - |
dc.date.issued | ACCEPT | - |
dc.identifier.citation | Future Oncology, Vol.20 No.8, pp.423-436 | - |
dc.identifier.issn | 1479-6694 | - |
dc.identifier.uri | https://hdl.handle.net/10371/195821 | - |
dc.description.abstract | Improving the prognosis for patients with metastatic HR+/HER2- breast cancer remains an unmet need. Patients with tumors that have progressed on endocrine therapy and/or are not eligible for endocrine therapy had limited treatment options beyond chemotherapy. Antibody-drug conjugates are a novel and promising treatment class in this setting. Datopotamab deruxtecan (Dato-DXd) consists of a TROP2-directed humanized IgG1 monoclonal antibody attached via a serum-stable cleavable linker to a topoisomerase I inhibitor payload. TROPION-Breast01 is an ongoing phase 3 study that is evaluating the efficacy and safety of Dato-DXd compared with investigator's choice of standard-of-care chemotherapy in patients with inoperable or metastatic HR+/HER2- breast cancer who have received one or two prior lines of systemic chemotherapy in the inoperable or metastatic setting. | - |
dc.language | 영어 | - |
dc.publisher | Future Medicine Ltd. | - |
dc.title | TROPION-Breast01: Datopotamab deruxtecan vs chemotherapy in pre-treated inoperable or metastatic HR+/HER2-breast cancer | - |
dc.type | Article | - |
dc.identifier.doi | 10.2217/fon-2023-0188 | - |
dc.citation.journaltitle | Future Oncology | - |
dc.identifier.wosid | 001021659000001 | - |
dc.identifier.scopusid | 2-s2.0-85188200861 | - |
dc.citation.endpage | 436 | - |
dc.citation.number | 8 | - |
dc.citation.startpage | 423 | - |
dc.citation.volume | 20 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Im, Seock-Ah | - |
dc.type.docType | Article; Early Access | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | ANTIBODY-DRUG CONJUGATE | - |
dc.subject.keywordPlus | TRASTUZUMAB DERUXTECAN | - |
dc.subject.keywordPlus | DS-8201A | - |
dc.subject.keywordPlus | RIBOCICLIB | - |
dc.subject.keywordPlus | GUIDELINE | - |
dc.subject.keywordPlus | ERIBULIN | - |
dc.subject.keywordPlus | THERAPY | - |
dc.subject.keywordAuthor | antibody-drug conjugate (ADC) | - |
dc.subject.keywordAuthor | datopotamab deruxtecan (Dato-DXd) | - |
dc.subject.keywordAuthor | HR-positive | - |
dc.subject.keywordAuthor | HER2-negative | - |
dc.subject.keywordAuthor | inoperable breast cancer | - |
dc.subject.keywordAuthor | metastatic breast cancer | - |
dc.subject.keywordAuthor | Trophoblast cell surface antigen 2 (TROP2) | - |
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