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Prognostic Impact of the Immunoscore Based on Whole-Slide Image Analysis of CD3+Tumor-Infiltrating Lymphocytes in Diffuse Large B-Cell Lymphoma
DC Field | Value | Language |
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dc.contributor.author | Han, Bogyeong | - |
dc.contributor.author | Yim, Jeemin | - |
dc.contributor.author | Lim, Sojung | - |
dc.contributor.author | Na, Sei | - |
dc.contributor.author | Lee, Cheol | - |
dc.contributor.author | Kim, Tae Min | - |
dc.contributor.author | Paik, Jin-Ho | - |
dc.contributor.author | Kim, Sehui | - |
dc.contributor.author | Jeon, Yoon Kyung | - |
dc.date.accessioned | 2023-10-30T01:44:33Z | - |
dc.date.available | 2023-10-30T01:44:33Z | - |
dc.date.created | 2023-08-14 | - |
dc.date.issued | 2023-09 | - |
dc.identifier.citation | Modern Pathology, Vol.36 No.9, p. 100224 | - |
dc.identifier.issn | 0893-3952 | - |
dc.identifier.uri | https://hdl.handle.net/10371/195833 | - |
dc.description.abstract | An Immunoscore based on tumor-infiltrating T-cell density was validated as a prognostic factor in patients with solid tumors. However, the potential utility of the Immunoscore in predicting the prognosis of patients with diffuse large B-cell lymphoma (DLBCL) is unclear. Here, the prognostic value of an Immunoscore based on tumor-infiltrating CD3+ T-cell density was evaluated in 104 patients with DLBCL who underwent R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisolone) therapy. Digitally scanned whole-slide images were analyzed using Aperio ImageScope software. CD3+ cell densities in the whole tumor area were quantitated using 3 different methods, including number of CD3+ cells/area (mm2), ratio of CD3+ cells to total cells, and ratio of CD3+ cells to CD20+ cells. There was a high concordance among the 3 methods. Patients with low CD3+ cell density had an elevated serum lactate dehydrogenase level and a high Ki-67 proliferation index (all, P < .05). Patients with low CD3+ cell density, according to all 3 methods, had worse overall survival (OS) and worse progression-free survival (P < .05, all). They also had poor OS, independent of MYC/BCL2 double expression (DE) status, Eastern Cooperative Oncology Group performance status, or Ann Arbor stage (all, P < .05). These results were validated using 2 publicly available data sets. In both validation cohorts, patients with low CD3E mRNA expression had an elevated serum lactate dehydrogenase level, extranodal site involvement, and DE status (P < .05). They also had worse progression-free survival (P =.067 and P =.002, respectively) and OS (both P < .05). A low CD3E mRNA level was predictive of poor OS, independent of DE status. An Immunoscore based on whole-slide image analysis of CD3+ T-cell infiltration was sufficient to predict survival in patients with DLBCL. Low CD3+ cell density was a poor prognostic factor, independent of other prognostic parameters and DE status.& COPY; 2023 United States & Canadian Academy of Pathology. Published by Elsevier Inc. All rights reserved. | - |
dc.language | 영어 | - |
dc.publisher | Nature Publishing Group | - |
dc.title | Prognostic Impact of the Immunoscore Based on Whole-Slide Image Analysis of CD3+Tumor-Infiltrating Lymphocytes in Diffuse Large B-Cell Lymphoma | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.modpat.2023.100224 | - |
dc.citation.journaltitle | Modern Pathology | - |
dc.identifier.wosid | 001038697600001 | - |
dc.identifier.scopusid | 2-s2.0-85172424634 | - |
dc.citation.number | 9 | - |
dc.citation.startpage | 100224 | - |
dc.citation.volume | 36 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Paik, Jin-Ho | - |
dc.contributor.affiliatedAuthor | Jeon, Yoon Kyung | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | IMMUNE CELLS | - |
dc.subject.keywordPlus | MICROENVIRONMENT | - |
dc.subject.keywordPlus | CLASSIFICATION | - |
dc.subject.keywordPlus | MACROPHAGES | - |
dc.subject.keywordPlus | DENSITY | - |
dc.subject.keywordAuthor | CD3 T-cell | - |
dc.subject.keywordAuthor | computational pathology | - |
dc.subject.keywordAuthor | diffuse large B-cell lymphoma | - |
dc.subject.keywordAuthor | digital pathology | - |
dc.subject.keywordAuthor | Immunoscore | - |
dc.subject.keywordAuthor | prognosis | - |
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