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Neutrophil/Lymphocyte Ratio in Patients Undergoing Noncardiac Surgery After Coronary Stent Implantation
DC Field | Value | Language |
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dc.contributor.author | Chung, Jaeyeon | - |
dc.contributor.author | Bae, Jinyoung | - |
dc.contributor.author | Kwon, Yongsuk | - |
dc.contributor.author | Yoon, Hyun-Kyu | - |
dc.contributor.author | Yoo, Seokha | - |
dc.contributor.author | Lee, Ho-Jim | - |
dc.contributor.author | Park, Sun-Kyung | - |
dc.contributor.author | Kim, Jin-Tae | - |
dc.contributor.author | Kim, Won Ho | - |
dc.date.accessioned | 2023-10-30T01:49:47Z | - |
dc.date.available | 2023-10-30T01:49:47Z | - |
dc.date.created | 2020-04-10 | - |
dc.date.issued | 2020-06 | - |
dc.identifier.citation | Journal of Cardiothoracic and Vascular Anesthesia, Vol.34 No.6, pp.1516-1525 | - |
dc.identifier.issn | 1053-0770 | - |
dc.identifier.uri | https://hdl.handle.net/10371/195895 | - |
dc.description.abstract | © 2019 Elsevier Inc.Objective: Perioperative cell count–associated predictors, including the neutrophil/lymphocyte ratio (N/LR) and platelet/lymphocyte ratio (P/LR), are associated with poor clinical outcomes including myocardial injury. Study investigators aimed to examine the association among the perioperative N/LR, P/LR, and postoperative major adverse cardiovascular and cerebral events (MACCE) after noncardiac surgery in patients with drug-eluting stent (DES) insertion. Design: Retrospective and observational. Setting: Single university hospital. Participants: The study comprised 965 patients who underwent noncardiac surgery within 6 months after DES implantation. Interventions: None. Measurements and Main Results: Baseline perioperative clinical parameters, including N/LR and P/LR measured before surgery, immediately after surgery, and on postoperative day (POD) 1, were obtained. MACCE was defined as a composite of nonfatal myocardial infarction, coronary revascularization, nonhemorrhagic stroke, and pulmonary embolism within 1 month after surgery. Multivariate logistic regression analysis and propensity score matching were used to identify predictors of MACCE after surgery. MACCE occurred in 67 patients (6.9%) and was more common in patients with N/LR on POD 1 >4.3 (multivariable-adjusted odds ratio [OR] 2.03, 95% confidence interval [CI] 1.12-2.79; p = 0.040 and as a continuous N/LR [OR 1.17, 95% CI 1.08-1.27; p < 0.001]). This association was consistent after propensity score matching and was stronger when the antiplatelet agent was stopped before surgery (OR 3.02, 95% CI 2.14-4.48; p = 0.006 for stopping dual antiplatelet therapy). Conclusions: In patients undergoing noncardiac surgery within 6 months after DES implantation, elevated N/LR on POD 1 is independently associated with postoperative MACCE. Elevated postoperative N/LR as a marker of systemic inflammation may help to predict the development of MACCE in these high-risk patients. | - |
dc.language | 영어 | - |
dc.publisher | W. B. Saunders Co., Ltd. | - |
dc.title | Neutrophil/Lymphocyte Ratio in Patients Undergoing Noncardiac Surgery After Coronary Stent Implantation | - |
dc.type | Article | - |
dc.identifier.doi | 10.1053/j.jvca.2019.10.009 | - |
dc.citation.journaltitle | Journal of Cardiothoracic and Vascular Anesthesia | - |
dc.identifier.wosid | 000530217000025 | - |
dc.identifier.scopusid | 2-s2.0-85075530886 | - |
dc.citation.endpage | 1525 | - |
dc.citation.number | 6 | - |
dc.citation.startpage | 1516 | - |
dc.citation.volume | 34 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Kim, Jin-Tae | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | NEUTROPHIL-LYMPHOCYTE RATIO | - |
dc.subject.keywordPlus | ACUTE KIDNEY INJURY | - |
dc.subject.keywordPlus | LONG-TERM MORTALITY | - |
dc.subject.keywordPlus | MYOCARDIAL-INFARCTION | - |
dc.subject.keywordPlus | RISK | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | RESECTION | - |
dc.subject.keywordPlus | PATHOPHYSIOLOGY | - |
dc.subject.keywordPlus | METAANALYSIS | - |
dc.subject.keywordPlus | PROGNOSIS | - |
dc.subject.keywordAuthor | surgery | - |
dc.subject.keywordAuthor | major adverse cardiovascular event | - |
dc.subject.keywordAuthor | coronary stent | - |
dc.subject.keywordAuthor | neutrophil | - |
dc.subject.keywordAuthor | lymphocyte | - |
dc.subject.keywordAuthor | platelet | - |
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