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Copeptin with high-sensitivity troponin at presentation is not inferior to serial troponin measurements for ruling out acute myocardial infarction
DC Field | Value | Language |
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dc.contributor.author | Kim, Kyung Su | - |
dc.contributor.author | Suh, Gil Joon | - |
dc.contributor.author | Song, Sang Hoon | - |
dc.contributor.author | Jung, Yoon Sun | - |
dc.contributor.author | Kim, Taegyun | - |
dc.contributor.author | Shin, So Mi | - |
dc.contributor.author | Kang, Min Woo | - |
dc.contributor.author | Lee, Min Sung | - |
dc.date.accessioned | 2023-10-30T02:02:22Z | - |
dc.date.available | 2023-10-30T02:02:22Z | - |
dc.date.created | 2020-05-11 | - |
dc.date.issued | 2020-03 | - |
dc.identifier.citation | Clinical and Experimental Emergency Medicine, Vol.7 No.1, pp.35-42 | - |
dc.identifier.issn | 2383-4625 | - |
dc.identifier.uri | https://hdl.handle.net/10371/196005 | - |
dc.description.abstract | Objective We aimed to compare the multi-marker strategy (copeptin and high-sensitivity cardiac troponin I [hs-cTnI]) with serial hs-cTnI measurements to rule out acute myocardial infarction (AMI) in patients with chest pain. Methods This prospective observational study was performed in a single emergency department. To test the non-inferiority margin of 4% in terms of negative predictive value (NPV) between the multi-marker strategy (0 hour) and serial hs-cTnI measurements (0 and 2 hours), 262 participants were required. Samples for copeptin and hs-cTnI assays were collected at presentation (0 hour) and after 2 hours. The measured biomarkers were considered abnormal when hs-cTnI was >26.2 ng/L and when copeptin was >10 pmol/L. Results AMI was diagnosed in 28 patients (10.7%). The NPV of the multi-marker strategy was 100% (160/160; 95% confidence interval [CI], 97.7% to 100%), which was not inferior to that of serial hs-cTnI measurements (201/201; 100%; 95% CI, 98.2% to 100%). The sensitivity, specificity, and positive predictive value of the multi-marker strategy were 100% (95% CI, 87.7% to 100%), 68.1% (95% CI, 61.7% to 74.0%), and 27.2% (95% CI, 18.9% to 36.8%), respectively. The sensitivity, specificity, and positive predictive value of serial hs-cTnI measurements were 100% (95% CI, 87.7% to 100%), 85.5% (95% CI, 80.4% to 89.8%), and 45.2% (95% CI, 32.5% to 58.3%), respectively. Conclusion The multi-marker strategy (copeptin and hs-cTnI measurement) was not inferior to serial hs-cTnI measurements in terms of NPV for AMI diagnosis, with a sensitivity and NPV of 100%. Copeptin may help in the early rule-out of AMI in patients with chest pain. | - |
dc.language | 영어 | - |
dc.publisher | 대한응급의학회 | - |
dc.title | Copeptin with high-sensitivity troponin at presentation is not inferior to serial troponin measurements for ruling out acute myocardial infarction | - |
dc.type | Article | - |
dc.identifier.doi | 10.15441/ceem.19.013 | - |
dc.citation.journaltitle | Clinical and Experimental Emergency Medicine | - |
dc.identifier.wosid | 000523300000006 | - |
dc.identifier.scopusid | 2-s2.0-85083295648 | - |
dc.citation.endpage | 42 | - |
dc.citation.number | 1 | - |
dc.citation.startpage | 35 | - |
dc.citation.volume | 7 | - |
dc.identifier.kciid | ART002579885 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Suh, Gil Joon | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | CARDIAC TROPONIN | - |
dc.subject.keywordPlus | RAPID RULE | - |
dc.subject.keywordPlus | INCREMENTAL VALUE | - |
dc.subject.keywordPlus | IMPROVES | - |
dc.subject.keywordPlus | ASSAYS | - |
dc.subject.keywordPlus | ULTRA | - |
dc.subject.keywordAuthor | Myocardial infarction | - |
dc.subject.keywordAuthor | Troponin I | - |
dc.subject.keywordAuthor | Biomarkers | - |
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