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Oleanane hemiacetal glycosides from Gymnema latifolium and their inhibitory effects on protein tyrosine phosphatase 1B

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dc.contributor.authorHa Thanh Tung Pham-
dc.contributor.authorRyu, Byeol-
dc.contributor.authorCho, Hyo Moon-
dc.contributor.authorLee, Ba-Wool-
dc.contributor.authorYang, Woo Young-
dc.contributor.authorPark, Eun Jin-
dc.contributor.authorVan On Tran-
dc.contributor.authorWon Keun Oh-
dc.date.accessioned2023-10-30T02:03:27Z-
dc.date.available2023-10-30T02:03:27Z-
dc.date.created2020-05-15-
dc.date.issued2020-02-
dc.identifier.citationPhytochemistry, Vol.170, p. 112181-
dc.identifier.issn0031-9422-
dc.identifier.urihttps://hdl.handle.net/10371/196025-
dc.description.abstractGymnema sylvestre (Retz.) R. Br. ex Schult. has a long history to be used as an antidiabetic herbal medicine. Various varieties of G. sylvestre, have been studied intensively on their 3 beta-hydroxy oleanane triterpenoid composition for hypoglycemic effects. It is also well-known that most species belonging to the same genus have similar chemical composition and biological activity. Thus, an extract of the Gymnema latifolium Wall. ex Wight, which showed considerable protein tyrosine phosphatase 1B (PTP1B) inhibitory activity (> 70% inhibition at 30 mu g/mL), was studied intensively. Extensive chemical investigation on the 70% EtOH of G. latifolium led to the isolation of four previously undescribed oleanane hemiacetal glycosides, gymlatinosides GL1-GL4, three previously undescribed oleanane glycosides, gymlatinosides GL5-GL7, and two known 3 beta-hydroxy oleanane analogs. The structures of the previously undescribed compounds were elucidated using diverse spectroscopic methods. The hemiacetal structure of the glycoside portion was further elaborated precisely by HMBC and J resolved proton NMR. Gymlatinosides GL2 and GL3 showed considerable PTP1B inhibitory effect.-
dc.language영어-
dc.publisherElsevier BV-
dc.titleOleanane hemiacetal glycosides from Gymnema latifolium and their inhibitory effects on protein tyrosine phosphatase 1B-
dc.typeArticle-
dc.identifier.doi10.1016/j.phytochem.2019.112181-
dc.citation.journaltitlePhytochemistry-
dc.identifier.wosid000508761600029-
dc.identifier.scopusid2-s2.0-85075419278-
dc.citation.startpage112181-
dc.citation.volume170-
dc.description.isOpenAccessN-
dc.contributor.affiliatedAuthorWon Keun Oh-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.subject.keywordPlusANTISWEET NATURAL-PRODUCTS-
dc.subject.keywordPlusSYLVESTRE-
dc.subject.keywordPlusASCLEPIADOIDEAE-
dc.subject.keywordPlusAPOCYNACEAE-
dc.subject.keywordPlusMONTANUM-
dc.subject.keywordPlusLEAVES-
dc.subject.keywordPlusACIDS-
dc.subject.keywordAuthorGymnema latifolium-
dc.subject.keywordAuthorApocynaceae-
dc.subject.keywordAuthorOleanane hemiacetal glycosides-
dc.subject.keywordAuthorPTP1B-
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