Publications
Detailed Information
The relationship between the effect-site concentration of propofol and sedation scale in children: a pharmacodynamic modeling study
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jang, Young-Eun | - |
dc.contributor.author | Ji, Sang-Hwan | - |
dc.contributor.author | Lee, Ji-Hyun | - |
dc.contributor.author | Kim, Eun-Hee | - |
dc.contributor.author | Kim, Jin-Tae | - |
dc.contributor.author | Kim, Hee-Soo | - |
dc.date.accessioned | 2023-12-11T00:42:38Z | - |
dc.date.available | 2023-12-11T00:42:38Z | - |
dc.date.created | 2021-09-28 | - |
dc.date.issued | 2021-09-09 | - |
dc.identifier.citation | BMC Anesthesiology, Vol.21 No.1, p. 222 | - |
dc.identifier.issn | 1471-2253 | - |
dc.identifier.uri | https://hdl.handle.net/10371/197701 | - |
dc.description.abstract | Background: Continuous infusion of propofol has been used to achieve sedation in children. However, the relationship between the effect-site concentration (C-e) of propofol and sedation scale has not been previously examined. The objective of this study was to investigate the relationship between the C-e of propofol and the University of Michigan Sedation Scale (UMSS) score in children with population pharmacodynamic modeling. Methods: A total of 30 patients (aged 3 to 6 years) who underwent surgery under general anesthesia with propofol and remifentanil lasting more than 1 h were enrolled in this study. Sedation levels were evaluated using the UMSS score every 20 s by a 1 mu g/mL stepwise increase in the C-e of propofol during the induction of anesthesia. The pharmacodynamic relationship between the C-e of propofol and UMSS score was analyzed by logistic regression with nonlinear mixed-effect modeling. Results: The estimated C-e50 (95% confidence interval) of propofol to yield UMSS scores equal to or greater than n were 1.84 (1.54-2.14), 2.64 (2.20-3.08), 3.98 (3.66-4.30), and 4.78 (4.53-5.03) mu g/mL for n = 1, 2, 3, and 4, respectively. The slope steepness for the relationship of the C-e versus sedative response to propofol (95% confidence interval) was 5.76 (4.00-7.52). Conclusions: We quantified the pharmacodynamic relationship between the C-e of propofol and UMSS score, and this finding may be helpful to predict the sedation score at the target C-e of propofol in children. | - |
dc.language | 영어 | - |
dc.publisher | BioMed Central | - |
dc.title | The relationship between the effect-site concentration of propofol and sedation scale in children: a pharmacodynamic modeling study | - |
dc.type | Article | - |
dc.identifier.doi | 10.1186/s12871-021-01446-y | - |
dc.citation.journaltitle | BMC Anesthesiology | - |
dc.identifier.wosid | 000694880500001 | - |
dc.identifier.scopusid | 2-s2.0-85114701739 | - |
dc.citation.number | 1 | - |
dc.citation.startpage | 222 | - |
dc.citation.volume | 21 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Kim, Jin-Tae | - |
dc.contributor.affiliatedAuthor | Kim, Hee-Soo | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | TARGET-CONTROLLED INFUSION | - |
dc.subject.keywordPlus | PEDIATRIC ANESTHESIA | - |
dc.subject.keywordPlus | PROCEDURAL SEDATION | - |
dc.subject.keywordPlus | PHARMACOKINETICS | - |
dc.subject.keywordPlus | PAEDFUSOR | - |
dc.subject.keywordPlus | SAFETY | - |
dc.subject.keywordPlus | DEPTH | - |
dc.subject.keywordAuthor | Anesthesia | - |
dc.subject.keywordAuthor | Anesthetics | - |
dc.subject.keywordAuthor | Pharmacodynamics | - |
dc.subject.keywordAuthor | Pharmacokinetics | - |
dc.subject.keywordAuthor | Sedation | - |
- Appears in Collections:
- Files in This Item:
- There are no files associated with this item.
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.