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Diagnostic and Prognostic ability of salivary MMP-9 and S100A8 for periodontitis
DC Field | Value | Language |
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dc.contributor.author | Kim, Hyun-Duck | - |
dc.contributor.author | Kim, Sungtae | - |
dc.contributor.author | Jeon, Sumin | - |
dc.contributor.author | Kim, Seon-Jip | - |
dc.contributor.author | Cho, Hyun-Jae | - |
dc.contributor.author | Choi, Young-Nim | - |
dc.date.accessioned | 2023-12-11T01:09:42Z | - |
dc.date.available | 2023-12-11T01:09:42Z | - |
dc.date.created | 2020-10-05 | - |
dc.date.issued | 2020-10 | - |
dc.identifier.citation | Journal of Clinical Periodontology, Vol.47 No.10, pp.1191-1200 | - |
dc.identifier.issn | 0303-6979 | - |
dc.identifier.uri | https://hdl.handle.net/10371/197910 | - |
dc.description.abstract | Objectives: Salivary diagnostic using matrix metalloproteinase (MMP) and S100 for periodontitis is a promising issue. However, its prognostic effect is still unclear. This study aimed to evaluate the prognostic ability of salivary MMP-9 and S100A8 for periodontitis through non-surgical periodontitis treatment clinical trial. Materials and Methods: Total 149 participants, 99 periodontitis and 50 healthy, were recruited. Among 99 non-surgical periodontitis treatment participants, 74 participants were revisited after three months. Periodontitis was classified as stage II-IV of new classification of periodontitis proposed at 2018. Enzyme-linked immunosorbent assay kit was used to quantify salivary MMP-9 and S100A8. Receiver operating characteristic curve was applied for diagnostic ability. Pairedttest was applied for prognostic ability evaluating changes in salivary markers between pre- and post-treatment. Results: Salivary MMP-9 and S100A8 were associated with periodontitis (p < .05). The screening ability of algorithm using salivary MMP-9 and S100A8 for periodontitis was 0.86 (p < .05). After treatment, reduction rate of salivary S100A8 and MMP-9 was 83.7% and 23.5%, respectively, (p < .05): only salivary S100A8 was superior compared to clinical parameters. Conclusion: Algorithm using salivary MMP-9 and S100A8 showed high diagnostic power for periodontitis. Both salivary S100A8 and MMP-9 showed prognostic ability for periodontitis, but S100A8 was better. | - |
dc.language | 영어 | - |
dc.publisher | Blackwell Publishing Inc. | - |
dc.title | Diagnostic and Prognostic ability of salivary MMP-9 and S100A8 for periodontitis | - |
dc.type | Article | - |
dc.identifier.doi | 10.1111/jcpe.13349 | - |
dc.citation.journaltitle | Journal of Clinical Periodontology | - |
dc.identifier.wosid | 000569269200001 | - |
dc.identifier.scopusid | 2-s2.0-85090950988 | - |
dc.citation.endpage | 1200 | - |
dc.citation.number | 10 | - |
dc.citation.startpage | 1191 | - |
dc.citation.volume | 47 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Kim, Hyun-Duck | - |
dc.contributor.affiliatedAuthor | Kim, Sungtae | - |
dc.contributor.affiliatedAuthor | Cho, Hyun-Jae | - |
dc.contributor.affiliatedAuthor | Choi, Young-Nim | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | CIGARETTE-SMOKING | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | ASSOCIATION | - |
dc.subject.keywordPlus | BIOMARKERS | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | MARKERS | - |
dc.subject.keywordAuthor | diagnosis | - |
dc.subject.keywordAuthor | MMP-9 | - |
dc.subject.keywordAuthor | periodontitis | - |
dc.subject.keywordAuthor | prognosis | - |
dc.subject.keywordAuthor | saliva | - |
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