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ERK-dependent IL-6 positive feedback loop mediates resistance against a combined treatment using danusertib and BKM120 in Burkitt lymphoma cell lines
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Liu, Jun | - |
dc.contributor.author | Hong, Junshik | - |
dc.contributor.author | Ahn, Kwang-Sung | - |
dc.contributor.author | Go, Junhyeok | - |
dc.contributor.author | Han, Heejoo | - |
dc.contributor.author | Park, Jihyun | - |
dc.contributor.author | Kim, Dongchan | - |
dc.contributor.author | Park, Hyejoo | - |
dc.contributor.author | Koh, Youngil | - |
dc.contributor.author | Shin, Dong-Yeop | - |
dc.contributor.author | Yoon, Sung-Soo | - |
dc.date.accessioned | 2023-12-11T05:15:51Z | - |
dc.date.available | 2023-12-11T05:15:51Z | - |
dc.date.created | 2020-03-31 | - |
dc.date.issued | 2019-08 | - |
dc.identifier.citation | Leukemia and Lymphoma, Vol.60 No.10, pp.2532-2540 | - |
dc.identifier.issn | 1042-8194 | - |
dc.identifier.uri | https://hdl.handle.net/10371/198186 | - |
dc.description.abstract | This study was conducted to define the synergistic effect of the PI3K inhibitor BKM120 with the pan-Aurora kinase inhibitor danusertib and the potential mechanism of resistance to the combined inhibitor treatment in Burkitt lymphoma cell lines. The combination of danusertib and BKM120 showed a synergistic effect on Namalwa cells but not on BJAB cells. The combined treatment led to ERK hyperactivation and induced IL-6 secretion in BJAB cells but not in Namalwa cells. A blockade of ERK signaling with trametinib suppressed the combination treatment-induced ERK activation, reduced IL-6 mRNA expression, and downregulated IL-6R mRNA expression, resulting in an improvement in the antitumor effect. We stepwise treated Namalwa cells with both inhibitors using on-and-off treatment cycles and found that Namalwa cells gained chemoresistance by activating the ERK/IL-6 feedback loop, suggesting that the ERK-dependent IL-6 positive feedback loop can compensate for AKT inactivation and is closely associated with adaptive resistance and relapse. | - |
dc.language | 영어 | - |
dc.publisher | Taylor & Francis | - |
dc.title | ERK-dependent IL-6 positive feedback loop mediates resistance against a combined treatment using danusertib and BKM120 in Burkitt lymphoma cell lines | - |
dc.type | Article | - |
dc.identifier.doi | 10.1080/10428194.2019.1594211 | - |
dc.citation.journaltitle | Leukemia and Lymphoma | - |
dc.identifier.wosid | 000489795900025 | - |
dc.identifier.scopusid | 2-s2.0-85063884218 | - |
dc.citation.endpage | 2540 | - |
dc.citation.number | 10 | - |
dc.citation.startpage | 2532 | - |
dc.citation.volume | 60 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Hong, Junshik | - |
dc.contributor.affiliatedAuthor | Yoon, Sung-Soo | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | AURORA KINASES | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | MYC | - |
dc.subject.keywordPlus | CHEMORESISTANCE | - |
dc.subject.keywordPlus | RITUXIMAB | - |
dc.subject.keywordPlus | SYNERGY | - |
dc.subject.keywordPlus | AKT | - |
dc.subject.keywordAuthor | Burkitt lymphoma | - |
dc.subject.keywordAuthor | BKM120 | - |
dc.subject.keywordAuthor | danusertib | - |
dc.subject.keywordAuthor | chemoresistance | - |
dc.subject.keywordAuthor | Aurora kinase | - |
dc.subject.keywordAuthor | PI3K | - |
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