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Deletion of CD1d in Adipocytes Aggravates Adipose Tissue Inflammation and Insulin Resistance in Obesity
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Huh, Jin Young | - |
dc.contributor.author | Park, Jeu | - |
dc.contributor.author | Kim, Jong In | - |
dc.contributor.author | Park, Yoon Jeong | - |
dc.contributor.author | Lee, Yun Kyung | - |
dc.contributor.author | Kim, Jae Bum | - |
dc.date.accessioned | 2023-12-11T06:29:31Z | - |
dc.date.available | 2023-12-11T06:29:31Z | - |
dc.date.created | 2018-09-05 | - |
dc.date.issued | 2017-04 | - |
dc.identifier.citation | Diabetes, Vol.66 No.4, pp.835-847 | - |
dc.identifier.issn | 0012-1797 | - |
dc.identifier.uri | https://hdl.handle.net/10371/198353 | - |
dc.description.abstract | Adipose tissue inflammation is an important factor in obesity that promotes insulin resistance. Among various cell types in adipose tissue, immune cells actively regulate inflammatory responses and affect whole-body energy metabolism. In particular, invariant natural killer T (iNKT) cells contribute to mitigating dysregulation of systemic energy homeostasis by counteracting obesity-induced inflammation in adipose tissue. However, the molecular mechanisms by which adipose iNKT cells become activated and mediate anti-inflammatory roles in obese adipose tissue have not been thoroughly understood yet. In the current study, we demonstrate that adipocyte CD1d plays a key role in the stimulation of adipose iNKT cells, leading to anti-inflammatory responses in high-fat diet (HFD)-fed mice. Accordingly, adipocyte-specific CD1d-knockout (CD1d(ADKO)) mice showed reduced numbers of iNKT cells in adipose tissues and decreased responses to alpha-galactosylceramide-induced iNKT cell activation. Additionally, HFD-fed CD1d(ADKO) mice revealed reduced interleukin-4 expression in adipose iNKT cells and aggravated adipose tissue inflammation and insulin resistance. Collectively, these data suggest that adipocytes could selectively stimulate adipose iNKT cells to mediate anti-inflammatory responses and attenuate excess proinflammatory responses in obese adipose tissue. | - |
dc.language | 영어 | - |
dc.publisher | American Diabetes Association | - |
dc.title | Deletion of CD1d in Adipocytes Aggravates Adipose Tissue Inflammation and Insulin Resistance in Obesity | - |
dc.type | Article | - |
dc.identifier.doi | 10.2337/db16-1122 | - |
dc.citation.journaltitle | Diabetes | - |
dc.identifier.wosid | 000397114900008 | - |
dc.identifier.scopusid | 2-s2.0-85019606361 | - |
dc.citation.endpage | 847 | - |
dc.citation.number | 4 | - |
dc.citation.startpage | 835 | - |
dc.citation.volume | 66 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Kim, Jae Bum | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | KILLER T-CELLS | - |
dc.subject.keywordPlus | DIET-INDUCED OBESITY | - |
dc.subject.keywordPlus | MACROPHAGE POLARIZATION | - |
dc.subject.keywordPlus | NKT CELLS | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | FAT | - |
dc.subject.keywordPlus | METABOLISM | - |
dc.subject.keywordPlus | MICE | - |
dc.subject.keywordPlus | INTERLEUKIN-4 | - |
dc.subject.keywordPlus | AXIS | - |
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