Publications
Detailed Information
IL-4/IL-4 Ab complex enhances the accumulation of both antigen-specific and bystander CD8 T cells in mouse lungs infected with influenza A virus
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, Hi Jung | - |
dc.contributor.author | Choi, Eun Ah | - |
dc.contributor.author | Choi, Sung Min | - |
dc.contributor.author | Choi, Young-Ki | - |
dc.contributor.author | Lee, Jae Il | - |
dc.contributor.author | Jung, Kyeong Cheon | - |
dc.date.accessioned | 2023-12-12T00:05:47Z | - |
dc.date.available | 2023-12-12T09:07:03Z | - |
dc.date.issued | 2023-12-01 | - |
dc.identifier.citation | Laboratory Animal Research. 2023 Dec 01;39(1):32 | ko_KR |
dc.identifier.issn | 2223-7660 | - |
dc.identifier.uri | https://hdl.handle.net/10371/198694 | - |
dc.description.abstract | Background
Unlike conventional T cells, innate and virtual-memory CD8 T cells in naïve mice acquire their memory phenotypes and functions in the absence of antigenic encounters in a cytokine-dependent manner. The relevant cytokines include interleukin-4 (IL-4), type I interferon, and interleukin-15 (IL-15). Moreover, exogenous IL-4 can also induce de novo generation and/or expansion of the virtual-memory CD8 T cell population. In this study, we investigated whether exogenous IL-4 could enhance the immune response to a viral infection. Results In vivo administration of IL-4 and an anti-IL-4 antibody complex (IL-4C) increased CXCR3 expression in both memory and naïve phenotype CD8 T cells in the absence of antigenic stimulation, and protected mice from lethal influenza infection. Flow cytometric analysis of lung-infiltrating immune cells on day 5 after virus infection revealed higher numbers of antigen-specific and bystander CD8 T cells in IL-4C-treated mice than in control mice. In particular, the bystander CD8 T cells were a naïve or evident memory phenotypes. Crucially, an anti-CXCR3 blocking antibody abrogated this IL-4C effect, reflecting that the increased accumulation of CD8 T cells in the lungs after IL-4C treatment is dependent on CXCR3. Conclusions These data demonstrate that exogenous IL-4C plays a protective role by enhancing CXCR3-dependent migration of CD8 T cells into influenza-infected lungs. | ko_KR |
dc.description.sponsorship | This work was supported by a grant from the National Research Foundation of Korea funded by the Korean government (Grant No. 2018R1D1A1B07043802) and the Research Fund from Seoul National University Hospital (Grant No. 0320200120) | ko_KR |
dc.language.iso | en | ko_KR |
dc.subject | Interlukin-4 | - |
dc.subject | Virtual memory | - |
dc.subject | CD8 T cells | - |
dc.subject | CXCR3 | - |
dc.subject | Influenza | - |
dc.title | IL-4/IL-4 Ab complex enhances the accumulation of both antigen-specific and bystander CD8 T cells in mouse lungs infected with influenza A virus | ko_KR |
dc.type | Article | ko_KR |
dc.identifier.doi | 10.1186/s42826-023-00183-2 | ko_KR |
dc.citation.journaltitle | BMC | ko_KR |
dc.language.rfc3066 | en | - |
dc.rights.holder | The Author(s) | - |
dc.date.updated | 2023-12-03T04:09:59Z | - |
dc.citation.number | 1 | ko_KR |
dc.citation.volume | 39 | ko_KR |
- Appears in Collections:
- Files in This Item:
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.