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c-MET-positive circulating tumor cells and cell-free DNA as independent prognostic factors in hormone receptor-positive/HER2-negative metastatic breast cancer
DC Field | Value | Language |
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dc.contributor.author | Park, Jieun | - |
dc.contributor.author | Chang, Eun Sol | - |
dc.contributor.author | Kim, Ji-Yeon | - |
dc.contributor.author | Chelakkot, Chaithanya | - |
dc.contributor.author | Sung, Minjung | - |
dc.contributor.author | Song, Ji-Young | - |
dc.contributor.author | Jung, Kyungsoo | - |
dc.contributor.author | Lee, Ji Hye | - |
dc.contributor.author | Choi, Jun Young | - |
dc.contributor.author | Kim, Na Young | - |
dc.contributor.author | Lee, Hyegyeong | - |
dc.contributor.author | Kang, Mi-Ran | - |
dc.contributor.author | Kwon, Mi Jeong | - |
dc.contributor.author | Shin, Young Kee | - |
dc.contributor.author | Park, Yeon Hee | - |
dc.contributor.author | Choi, Yoon-La | - |
dc.date.accessioned | 2024-01-22T00:53:24Z | - |
dc.date.available | 2024-01-22T09:54:27Z | - |
dc.date.issued | 2024-01-18 | - |
dc.identifier.citation | Breast Cancer Research,Vol.26, no.13 | ko_KR |
dc.identifier.issn | 1465-542X | - |
dc.identifier.uri | https://hdl.handle.net/10371/198932 | - |
dc.description.abstract | Background
Endocrine therapy resistance in hormone receptor-positive/HER2-negative (HR+/HER2−) breast cancer (BC) is a significant clinical challenge that poses several unmet needs in the management of the disease. This study aimed to investigate the prognostic value of c-MET-positive circulating tumor cells (cMET+ CTCs), ESR1/PIK3CA mutations, and cell-free DNA (cfDNA) concentrations in patients with hormone receptor-positive (HR+) metastatic breast cancer (mBC). Methods Ninety-seven patients with HR+ mBC were prospectively enrolled during standard treatment at Samsung Medical Center. CTCs were isolated from blood using GenoCTC® and EpCAM or c-MET CTC isolation kits. PIK3CA and ESR1 hotspot mutations were analyzed using droplet digital PCR. CfDNA concentrations were calculated using internal control copies from the ESR1 mutation test. Immunocytochemistry was performed to compare c-MET overexpression between primary and metastatic sites. Results The proportion of c-MET overexpression was significantly higher in metastatic sites than in primary sites (p = 0.00002). Survival analysis showed that c-MET+ CTC, cfDNA concentration, and ESR1 mutations were significantly associated with poor prognosis (p = 0.0026, 0.0021, and 0.0064, respectively) in HR+/HER2− mBC. By contrast, EpCAM-positive CTC (EpCAM+ CTC) and PIK3CA mutations were not associated with progression-free survival (PFS) in HR+/HER2− mBC. Multivariate analyses revealed that c-MET+ CTCs and cfDNA concentration were independent predictors of PFS in HR+/HER2− mBC. Conclusions Monitoring c-MET+ CTC, rather than assessing c-MET expression in the primary BC site, could provide valuable information for predicting disease progression, as c-MET expression can change during treatment. The c-MET+ CTC count and cfDNA concentration could provide complementary information on disease progression in HR+ /HER2− mBC, highlighting the importance of integrated liquid biopsy. | ko_KR |
dc.description.sponsorship | This research was supported by Grants from the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI) funded by the Ministry of Health & Welfare (HI19C0141; to ES Chang, M Sung, JY Song, K Jung, and YL Choi), Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (2022R1A6A1A03046247; to YK Shin), NRF Grant funded by the Ministry of Science and ICT (2022R1A2C2006322; to ES Chang, M Sung, JY Song, K Jung, and YL Choi), and Future Medicine 20*30 Project of the Samsung Medical Center (#SMO1230021; to YL Choi), Republic of Korea | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | BMC | ko_KR |
dc.subject | Metastatic breast cancer | - |
dc.subject | Circulating tumor cells | - |
dc.subject | Prognostic biomarkers | - |
dc.subject | c-MET | - |
dc.subject | Cell-free DNA | - |
dc.title | c-MET-positive circulating tumor cells and cell-free DNA as independent prognostic factors in hormone receptor-positive/HER2-negative metastatic breast cancer | ko_KR |
dc.type | Article | ko_KR |
dc.identifier.doi | 10.1186/s13058-024-01768-y | ko_KR |
dc.citation.journaltitle | Breast Cancer Research | ko_KR |
dc.language.rfc3066 | en | - |
dc.rights.holder | The Author(s) | - |
dc.date.updated | 2024-01-21T04:17:35Z | - |
dc.citation.endpage | 17 | ko_KR |
dc.citation.number | 13 | ko_KR |
dc.citation.startpage | 1 | ko_KR |
dc.citation.volume | 26 | ko_KR |
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