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Independent association of thigh muscle fat density with vascular events in Korean adults
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Choe, Hun Jee | - |
dc.contributor.author | Chang, Won | - |
dc.contributor.author | Blüher, Matthias | - |
dc.contributor.author | Heymsfield, Steven B. | - |
dc.contributor.author | Lim, Soo | - |
dc.date.accessioned | 2024-02-05T01:16:20Z | - |
dc.date.available | 2024-02-05T10:17:05Z | - |
dc.date.issued | 2024-01-28 | - |
dc.identifier.citation | Cardiovascular Diabetology, Vol.23, no.44 | ko_KR |
dc.identifier.issn | 1475-2840 | - |
dc.identifier.uri | https://hdl.handle.net/10371/198980 | - |
dc.description.abstract | Background
We aimed to explore the associations between thigh muscle fat density and vascular events. Methods A total of 3,595 adults (mean age, 57.2 years; women, 1,715 [47.7%]) without baseline cardiovascular events from the Korean Atherosclerosis Study-2 were included. Muscle and fat area at the mid-thigh level were measured by computed tomography (CT) using the following Hounsfield Unit range: 0–30 for low density muscle (LDM); 31–100 for normal density muscle (NDM); and − 250 to − 50 for fat. Results During a median follow-up period of 11.8 (4.3–13.9) years, vascular events occurred in 11.6% of men and 5.9% of women. Individuals with vascular events had a larger LDM area (men: 48.8 ± 15.5 cm2 vs. 44.6 ± 14.5 cm2; women: 39.4 ± 13.2 cm2 vs. 35.0 ± 11.8 cm2, both P < 0.001) compared with those who did not have vascular events during the follow-up of at least 5 years. The LDM/NDM ratio was also independently associated with vascular events after adjusting for cardiometabolic risk factors. Moreover, the LDM/NDM ratio improved the prognostic value for vascular events when added to conventional risk factors. Conclusions The current study suggests that a higher thigh muscle fat infiltration is associated with an increased risk of developing vascular events among Korean adults. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | BMC | ko_KR |
dc.subject | Myosteatosis | - |
dc.subject | Ectopic fat | - |
dc.subject | Coronary artery disease | - |
dc.subject | Cardiovascular disease | - |
dc.title | Independent association of thigh muscle fat density with vascular events in Korean adults | ko_KR |
dc.type | Article | ko_KR |
dc.identifier.doi | 10.1186/s12933-024-02138-w | ko_KR |
dc.citation.journaltitle | Cardiovascular Diabetology | ko_KR |
dc.language.rfc3066 | en | - |
dc.rights.holder | The Author(s) | - |
dc.date.updated | 2024-02-04T04:21:59Z | - |
dc.citation.endpage | 12 | ko_KR |
dc.citation.number | 44 | ko_KR |
dc.citation.startpage | 1 | ko_KR |
dc.citation.volume | 23 | ko_KR |
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