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Association between brain amyloid deposition and longitudinal changes of white matter hyperintensities
DC Field | Value | Language |
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dc.contributor.author | Cha, Woo-Jin | - |
dc.contributor.author | Yi, Dahyun | - |
dc.contributor.author | Ahn, Hyejin | - |
dc.contributor.author | Byun, Min Soo | - |
dc.contributor.author | Chang, Yoon Young | - |
dc.contributor.author | Choi, Jung-Min | - |
dc.contributor.author | Kim, Kyungtae | - |
dc.contributor.author | Choi, Hyeji | - |
dc.contributor.author | Jung, Gijung | - |
dc.contributor.author | Kang, Koung Mi | - |
dc.contributor.author | Sohn, Chul-Ho | - |
dc.contributor.author | Lee, Yun-Sang | - |
dc.contributor.author | Kim, Yu Kyeong | - |
dc.contributor.author | Lee, Dong Young | - |
dc.date.accessioned | 2024-03-13T02:34:25Z | - |
dc.date.available | 2024-03-13T11:35:22Z | - |
dc.date.issued | 2024-03-07 | - |
dc.identifier.citation | Alzheimer's Research & Therapy Vol.16, no.50 | ko_KR |
dc.identifier.issn | 1758-9193 | - |
dc.identifier.uri | https://hdl.handle.net/10371/199117 | - |
dc.description.abstract | Background
Growing evidence suggests that not only cerebrovascular disease but also Alzheimers disease (AD) pathological process itself cause cerebral white matter degeneration, resulting in white matter hyperintensities (WMHs). Some preclinical evidence also indicates that white matter degeneration may precede or affect the development of AD pathology. This study aimed to clarify the direction of influence between in vivo AD pathologies, particularly beta-amyloid (Aβ) and tau deposition, and WMHs through longitudinal approach. Methods Total 282 older adults including cognitively normal and cognitively impaired individuals were recruited from the Korean Brain Aging Study for the Early Diagnosis and Prediction of Alzheimers Disease (KBASE) cohort. The participants underwent comprehensive clinical and neuropsychological assessment, [11C] Pittsburgh Compound B PET for measuring Aβ deposition, [18F] AV-1451 PET for measuring tau deposition, and MRI scans with fluid-attenuated inversion recovery image for measuring WMH volume. The relationships between Aβ or tau deposition and WMH volume were examined using multiple linear regression analysis. In this analysis, baseline Aβ or tau were used as independent variables, and change of WMH volume over 2 years was used as dependent variable to examine the effect of AD pathology on increase of WMH volume. Additionally, we set baseline WMH volume as independent variable and longitudinal change of Aβ or tau deposition for 2 years as dependent variables to investigate whether WMH volume could precede AD pathologies. Results Baseline Aβ deposition, but not tau deposition, had significant positive association with longitudinal change of WMH volume over 2 years. Baseline WMH volume was not related with any of longitudinal change of Aβ or tau deposition for 2 years. We also found a significant interaction effect between baseline Aβ deposition and sex on longitudinal change of WMH volume. Subsequent subgroup analyses showed that high baseline Aβ deposition was associated with increase of WMH volume over 2 years in female, but not in male. Conclusions Our findings suggest that Aβ deposition accelerates cerebral WMHs, particularly in female, whereas white matter degeneration appears not influence on longitudinal Aβ increase. The results also did not support any direction of influence between tau deposition and WMHs. | ko_KR |
dc.description.sponsorship | This study was supported by grants from the Ministry of Science, ICT, and Future Planning, Republic of Korea (Grant No: NRF-2014M3C7A1046042 & NRF-2020R1G1A1099652) and grants of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (Grant No: HI18C0630 & HI19C0149), and a grant from the National Institute of Aging, United States of America (U01AG072177). | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | BMC | ko_KR |
dc.subject | Alzheimer’s disease | - |
dc.subject | Beta-amyloid | - |
dc.subject | Tau | - |
dc.subject | White matter hyperintensity | - |
dc.subject | Sex difference | - |
dc.title | Association between brain amyloid deposition and longitudinal changes of white matter hyperintensities | ko_KR |
dc.type | Article | ko_KR |
dc.identifier.doi | 10.1186/s13195-024-01417-8 | ko_KR |
dc.citation.journaltitle | Alzheimer's Research & Therapy | ko_KR |
dc.language.rfc3066 | en | - |
dc.rights.holder | The Author(s) | - |
dc.date.updated | 2024-03-10T04:09:09Z | - |
dc.citation.endpage | 9 | ko_KR |
dc.citation.number | 50 | ko_KR |
dc.citation.startpage | 1 | ko_KR |
dc.citation.volume | 16 | ko_KR |
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