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Strategy to develop broadly effective multivalent COVID-19 vaccines against emerging variants based on Ad5/35 platform
DC Field | Value | Language |
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dc.contributor.author | Chang, Soojeong | - |
dc.contributor.author | Shin, Kwang-Soo | - |
dc.contributor.author | Park, Bongju | - |
dc.contributor.author | Park, Seowoo | - |
dc.contributor.author | Shin, Jieun | - |
dc.contributor.author | Park, Hyemin | - |
dc.contributor.author | Jung, In Kyung | - |
dc.contributor.author | Kim, Jong Heon | - |
dc.contributor.author | Bae, Seong Eun | - |
dc.contributor.author | Kim, Jae-Ouk | - |
dc.contributor.author | Baek, Seung Ho | - |
dc.contributor.author | Kim, Green | - |
dc.contributor.author | Hong, Jung Joo | - |
dc.contributor.author | Seo, Hyungseok | - |
dc.contributor.author | Volz, Erik | - |
dc.contributor.author | Kang, Chang-Yuil | - |
dc.date.accessioned | 2024-03-20T06:02:01Z | - |
dc.date.available | 2024-03-20T06:02:01Z | - |
dc.date.created | 2024-03-20 | - |
dc.date.created | 2024-03-20 | - |
dc.date.created | 2024-03-20 | - |
dc.date.created | 2024-03-20 | - |
dc.date.issued | 2024-03 | - |
dc.identifier.citation | Proceedings of the National Academy of Sciences of the United States of America, Vol.121 No.10, p. 2313681121 | - |
dc.identifier.issn | 0027-8424 | - |
dc.identifier.uri | https://hdl.handle.net/10371/199120 | - |
dc.description.abstract | The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron strain has evolved into highly divergent variants with several sub-lineages. These newly emerging variants threaten the efficacy of available COVID-19 vaccines. To mitigate the occurrence of breakthrough infections and re-infections, and more importantly, to reduce the disease burden, it is essential to develop a strategy for producing updated multivalent vaccines that can provide broad neutralization against both currently circulating and emerging variants. We developed bivalent vaccine AdCLD-CoV19-1 BA.5/BA.2.75 and trivalent vaccines AdCLD-CoV19-1 XBB/BN.1/BQ.1.1 and AdCLD-CoV19-1 XBB.1.5/BN.1/BQ.1.1 using an Ad5/35 platform-based non-replicating recombinant adenoviral vector. We compared immune responses elicited by the monovalent and multivalent vaccines in mice and macaques. We found that the BA.5/BA.2.75 bivalent and the XBB/BN.1/BQ.1.1 and XBB.1.5/BN.1/BQ.1.1 trivalent vaccines exhibited improved cross-neutralization ability compared to their respective monovalent vaccines. These data suggest that the developed multivalent vaccines enhance immunity against circulating Omicron subvariants and effectively elicit neutralizing antibodies across a broad spectrum of SARS-CoV-2 variants. | - |
dc.language | 영어 | - |
dc.publisher | National Academy of Sciences | - |
dc.title | Strategy to develop broadly effective multivalent COVID-19 vaccines against emerging variants based on Ad5/35 platform | - |
dc.type | Article | - |
dc.identifier.doi | 10.1073/pnas.2313681121 | - |
dc.citation.journaltitle | Proceedings of the National Academy of Sciences of the United States of America | - |
dc.identifier.wosid | 001207786500007 | - |
dc.identifier.scopusid | 2-s2.0-85186750511 | - |
dc.citation.number | 10 | - |
dc.citation.startpage | 2313681121 | - |
dc.citation.volume | 121 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Seo, Hyungseok | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | ANTIGENIC CARTOGRAPHY | - |
dc.subject.keywordPlus | ADENOVIRUS | - |
dc.subject.keywordPlus | IMMUNOGENICITY | - |
dc.subject.keywordPlus | SAFETY | - |
dc.subject.keywordPlus | INFECTION | - |
dc.subject.keywordPlus | BOOSTER | - |
dc.subject.keywordPlus | BLIND | - |
dc.subject.keywordAuthor | chimeric adenovirus-vectored vaccine | - |
dc.subject.keywordAuthor | COVID-19 vaccine | - |
dc.subject.keywordAuthor | multivalent vaccine | - |
dc.subject.keywordAuthor | neutralizing activity | - |
dc.subject.keywordAuthor | SARS-CoV-2 variants | - |
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