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Subacute toxicity and toxicokinetics study of DHP107, an oral paclitaxel formulation with once-weekly dosing in mice
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Ji-Young | - |
dc.contributor.author | Lee, Sunyeong | - |
dc.contributor.author | Kim, Yongbum | - |
dc.contributor.author | Jeong, Eun Ju | - |
dc.contributor.author | Lee, In Hyun | - |
dc.contributor.author | Son, Min-Hee | - |
dc.contributor.author | Lee, Jae Young | - |
dc.contributor.author | Kim, Sang Kyum | - |
dc.contributor.author | Moon, Kyoung-Sik | - |
dc.date.accessioned | 2024-04-26T00:25:26Z | - |
dc.date.available | 2024-04-26T00:25:26Z | - |
dc.date.created | 2024-04-25 | - |
dc.date.issued | 2019-04 | - |
dc.identifier.citation | REGULATORY TOXICOLOGY AND PHARMACOLOGY, Vol.103, pp.196-204 | - |
dc.identifier.issn | 0273-2300 | - |
dc.identifier.uri | https://hdl.handle.net/10371/199489 | - |
dc.description.abstract | DHP107, an oral formulation of paclitaxel, is effectively and systemically absorbed in intestinal endothelial cells. Although the in vivo efficacy of DHP107 has been reported, the potential toxicity of DHP107 has not been evaluated. Therefore, this study was conducted to evaluate the toxicity and toxicokinetics of DHP107 orally administered to ICR mice at 25, 50, and 100 mg/kg via once-weekly dosing for six weeks. DHP107-related clinical signs were observed in both sexes at 100 mg/kg. There were significant increases in the number of platelets and percentages of reticulocytes and basophils in male mice. Also in males, there was a significant decrease in the absolute and relative weights of testes, epididymides, kidneys, and heart. Relative spleen weights were significantly increased in males treated with doses >= 50 mg/kg which had histopathological correlates. These changes were reversible after a two-week recovery period with the exception of the findings in the reproductive organs. Systemic exposure to paclitaxel increased with DHP107 doses in single and multiple dosing with no marked differences between sexes. In conclusion, the target organs were determined to be the reproductive and hematopoietic organs in male mice, suggesting of sex difference and the NOAEL of DHP107 was established to be < 25 mg/kg for males and 50 mg/kg for females. | - |
dc.language | 영어 | - |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | - |
dc.title | Subacute toxicity and toxicokinetics study of DHP107, an oral paclitaxel formulation with once-weekly dosing in mice | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.yrtph.2019.02.004 | - |
dc.citation.journaltitle | REGULATORY TOXICOLOGY AND PHARMACOLOGY | - |
dc.identifier.wosid | 000476683100023 | - |
dc.identifier.scopusid | 2-s2.0-85061446410 | - |
dc.citation.endpage | 204 | - |
dc.citation.startpage | 196 | - |
dc.citation.volume | 103 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Lee, Jae Young | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | ADVANCED SOLID TUMORS | - |
dc.subject.keywordPlus | TISSUE DISTRIBUTION | - |
dc.subject.keywordPlus | PHASE-I | - |
dc.subject.keywordPlus | TAXOL | - |
dc.subject.keywordPlus | DRUG | - |
dc.subject.keywordPlus | ABSORPTION | - |
dc.subject.keywordPlus | EFFICACY | - |
dc.subject.keywordPlus | NEUROTOXICITY | - |
dc.subject.keywordPlus | CHEMOTHERAPY | - |
dc.subject.keywordAuthor | Oral formulated paclitaxel | - |
dc.subject.keywordAuthor | DHP107 | - |
dc.subject.keywordAuthor | Subacute oral toxicity | - |
dc.subject.keywordAuthor | No-observed-adverse-effect level (NOAEL) | - |
dc.subject.keywordAuthor | Toxicokinetics | - |
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