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Rise in broadly cross-reactive adaptive immunity against human β-coronaviruses in MERS-recovered patients during the COVID-19 pandemic
DC Field | Value | Language |
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dc.contributor.author | Kim, So-Hee | - |
dc.contributor.author | Kim, Yuri | - |
dc.contributor.author | Jeon, Sangeun | - |
dc.contributor.author | Park, Uni | - |
dc.contributor.author | Kang, Ju-Il | - |
dc.contributor.author | Jeon, Kyeongseok | - |
dc.contributor.author | Kim, Hye-Ran | - |
dc.contributor.author | Oh, Songhyeok | - |
dc.contributor.author | Rhee, Ji-Young | - |
dc.contributor.author | Choi, Jae-Phil | - |
dc.contributor.author | Park, Wan Beom | - |
dc.contributor.author | Park, Sang Won | - |
dc.contributor.author | Yang, Jeong-Sun | - |
dc.contributor.author | Lee, Joo-Yeon | - |
dc.contributor.author | Kang, Jihye | - |
dc.contributor.author | Shin, Hyoung-Shik | - |
dc.contributor.author | Kim, Yeonjae | - |
dc.contributor.author | Kim, Seungtaek | - |
dc.contributor.author | Kim, Yeon-Sook | - |
dc.contributor.author | Lim, Dong-Gyun | - |
dc.contributor.author | Cho, Nam-Hyuk | - |
dc.date.accessioned | 2024-04-26T00:56:34Z | - |
dc.date.available | 2024-04-26T00:56:34Z | - |
dc.date.created | 2024-03-20 | - |
dc.date.issued | 2024-02 | - |
dc.identifier.citation | Science Advances, Vol.10 No.9, p. 6425 | - |
dc.identifier.issn | 2375-2548 | - |
dc.identifier.uri | https://hdl.handle.net/10371/199556 | - |
dc.description.abstract | To develop a universal coronavirus (CoV) vaccine, long-term immunity against multiple CoVs, including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants, Middle East respiratory syndrome (MERS)–CoV, and future CoV strains, is crucial. Following the 2015 Korean MERS outbreak, we conducted a long-term follow-up study and found that although neutralizing antibodies and memory T cells against MERS-CoV declined over 5 years, some recovered patients exhibited increased antibody levels during the COVID-19 pandemic. This likely resulted from cross-reactive immunity induced by SARS-CoV-2 vaccines or infections. A significant correlation in antibody responses across various CoVs indicates shared immunogenic epitopes. Two epitopes—the spike proteins stem helix and intracellular domain—were highly immunogenic after MERS-CoV infection and after SARS-CoV-2 vaccination or infection. In addition, memory T cell responses, especially polyfunctional CD4+ T cells, were enhanced during the pandemic, correlating significantly with MERS-CoV spike-specific antibodies and neutralizing activity. Therefore, incorporating these cross-reactive and immunogenic epitopes into pan-CoV vaccine formulations may facilitate effective vaccine development. | - |
dc.language | 영어 | - |
dc.publisher | American Association for the Advancement of Science | - |
dc.title | Rise in broadly cross-reactive adaptive immunity against human β-coronaviruses in MERS-recovered patients during the COVID-19 pandemic | - |
dc.type | Article | - |
dc.identifier.doi | 10.1126/sciadv.adk6425 | - |
dc.citation.journaltitle | Science Advances | - |
dc.identifier.wosid | 001186126800002 | - |
dc.identifier.scopusid | 2-s2.0-85186740495 | - |
dc.citation.number | 9 | - |
dc.citation.startpage | 6425 | - |
dc.citation.volume | 10 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Park, Wan Beom | - |
dc.contributor.affiliatedAuthor | Park, Sang Won | - |
dc.contributor.affiliatedAuthor | Cho, Nam-Hyuk | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | CELL RESPONSES | - |
dc.subject.keywordPlus | SARS-COV-2 | - |
dc.subject.keywordPlus | ANTIBODIES | - |
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