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Evaluation of bone healing using rhBMP-2 soaked hydroxyapatite in ridge augmentation: A prospective observational study
DC Field | Value | Language |
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dc.contributor.author | Kim, Hyun Suk | - |
dc.contributor.author | Park, Joo Cheol | - |
dc.contributor.author | Yun, Pil Young | - |
dc.contributor.author | Kim, Young Kyun | - |
dc.date.accessioned | 2024-05-01T01:31:57Z | - |
dc.date.available | 2024-05-01T01:31:57Z | - |
dc.date.created | 2018-10-01 | - |
dc.date.issued | 2017-12 | - |
dc.identifier.citation | Maxillofacial Plastic Reconstructive Surgery, Vol.39 No.1, p. 40 | - |
dc.identifier.issn | 2288-8586 | - |
dc.identifier.uri | https://hdl.handle.net/10371/200119 | - |
dc.description.abstract | Background: The goal of this study is to evaluate complication and effectiveness of alveolar ridge augmentations using a hydroxyapatite-based alloplastic bony substitute with rhBMP-2. Methods: A total of 10 patients (4 males, 6 females; 58.5 ± 8.6 years) participated in this clinical research. Alveolar ridge augmentations were performed in edentulous (4 maxillary posterior, 5 mandibular posterior, and 1 mandibular anterior) regions. Anorganic bovine bone (ABB; Bio-Oss®, Geistlich Pharma AG, Wolhusen, Switzerland) was used as the bone graft material in the control group (n = 5)) while hydroxyapatite-based alloplastic bony substitute with rhBMP-2(HA+rhBMP-2; NOVOSIS®-Dent, CGBio Inc., Seongnam, Korea) was used in the experimental group (n = 5). In order to evaluate relative changes in bone volume and resorption rate of the bone graft material, CBCT radiographs were taken immediately and at 4 months after the bone graft in all subjects. Among the 10 patients, 8 received dental implants in Seoul National University Bundang Hospital, while the others received in local clinics. Bone specimens for further histomorphometric examinations were gained from these 8 patients using trephine burs during the implant placements. Clinical, radiographic, and histomorphometric evaluations were focused because of the small sample size. Results: When CBCT radiographs were compared between immediately and at 4.07 ± 0.13 months after the bone graft, both alveolar bone widths (ABB 2.52 ± 0.18 mm, HA+rhBMP-2 1.75 ± 0.85 mm) and heights (ABB 1.68 ± 0.17 mm, HA+rhBMP-2 1.57 ± 0.28 mm) increased in the two groups. Resorption rates of transplanted bone graft material in the alveolar bone widths and heights were (ABB 29.7 ± 8.8%, HA+rhBMP-2 31.5 ± 7.4%) and (ABB 39.2 ± 21.8%, HA+rhBMP-2 52.6 ± 6.5%), respectively. Histomorphometrically, ABB group showed bone formation via osteoconduction and HA+rhBMP-2 group via osteoinduction. HA+rhBMP-2 group showed more bone formation around the bone graft materials than the ABB group. Postoperative complications were not found in all subjects. Conclusions: Our study had following conclusions: (1) Ridge augmentations using HA+rhBMP-2 could be clinically useful to supplement implant placements in edentulous regions. (2) Serious postoperative complications related to the graft material did not occur. | - |
dc.language | 영어 | - |
dc.publisher | 대한악안면성형재건외과학회 | - |
dc.title | Evaluation of bone healing using rhBMP-2 soaked hydroxyapatite in ridge augmentation: A prospective observational study | - |
dc.type | Article | - |
dc.identifier.doi | 10.1186/s40902-017-0138-9 | - |
dc.citation.journaltitle | Maxillofacial Plastic Reconstructive Surgery | - |
dc.identifier.scopusid | 2-s2.0-85050408214 | - |
dc.citation.number | 1 | - |
dc.citation.startpage | 40 | - |
dc.citation.volume | 39 | - |
dc.identifier.kciid | ART002307399 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Park, Joo Cheol | - |
dc.contributor.affiliatedAuthor | Yun, Pil Young | - |
dc.contributor.affiliatedAuthor | Kim, Young Kyun | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | MORPHOGENETIC PROTEIN-2 | - |
dc.subject.keywordPlus | REGENERATION | - |
dc.subject.keywordAuthor | Alveolar ridge augmentation | - |
dc.subject.keywordAuthor | Bone morphogenetic protein 2 | - |
dc.subject.keywordAuthor | Bone regeneration | - |
dc.subject.keywordAuthor | Hydroxyapatite | - |
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